Scientific African, 2023 Bisphenols are known to be endocrine disruptors. They are ubiquitous in the environment and also in plastic materials such as those used in food packaging.
Olivier Songue Same +4 more
doaj +2 more sources
Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods. [PDF]
PLoS Computational Biology, 2010 Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with a tiny number of complexes being ...
Christelle Reynès +9 more
doaj +2 more sources
High pressure jet injection of viscous solutions for endoscopic submucosal dissection (ESD): first clinical experience [PDF]
Endoscopy International Open, 2015 Background: Long lasting elevation is a key factor during endoscopic submucosal dissection (ESD) and can be obtained by water jet injection of saline solution or by viscous macromolecular solutions. In a previous animal study, we assessed the Nestis Enki
Mathieu Pioche +13 more
doaj +2 more sources
Two-long terminal repeat (LTR) DNA circles are a substrate for HIV-1 integrase. [PDF]
J Biol Chem, 2019 Integration of the HIV-1 DNA into the host genome is essential for viral replication and is catalyzed by the retroviral integrase. To date, the only substrate described to be involved in this critical reaction is the linear viral DNA produced in reverse ...
Richetta C +10 more
europepmc +2 more sources
Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. [PDF]
Retrovirology, 2015 BackgroundGenomic integration, an obligate step in the HIV-1 replication cycle, is blocked by the integrase inhibitor raltegravir. A consequence is an excess of unintegrated viral DNA genomes, which undergo intramolecular ligation and accumulate as 2-LTR
Thierry S +13 more
europepmc +2 more sources
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration. [PDF]
J Virol, 2022 Richetta C +13 more
europepmc +2 more sources
The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation. [PDF]
Nucleic Acids Res, 2009 Raltegravir (MK-0518) is the first integrase (IN) inhibitor to be approved by the US FDA and is currently used in clinical treatment of viruses resistant to other antiretroviral compounds.
Delelis O +8 more
europepmc +2 more sources
Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle. [PDF]
Retrovirology, 2013 BackgroundHIV-1 DNA is found both integrated in the host chromosome and unintegrated in various forms: linear (DNAL) or circular (1-LTRc, 2-LTRc or products of auto-integration). Here, based on pre-established strategies, we extended and characterized in
Munir S +4 more
europepmc +2 more sources
Opposite transcriptional regulation of integrated vs unintegrated HIV genomes by the NF-κB pathway. [PDF]
Sci Rep, 2016 Integration of HIV-1 linear DNA into host chromatin is required for high levels of viral expression, and constitutes a key therapeutic target. Unintegrated viral DNA (uDNA) can support only limited transcription but may contribute to viral propagation ...
Thierry S +6 more
europepmc +2 more sources
Comparative study of the fatty acid binding process of a new FABP from Cherax quadricarinatus by fluorescence intensity, lifetime and anisotropy. [PDF]
PLoS ONE, 2012 Fatty acid-binding proteins (FABPs) are small cytosolic proteins, largely distributed in invertebrates and vertebrates, which accomplish uptake and intracellular transport of hydrophobic ligands such as fatty acids.
Jiayao Li +9 more
doaj +2 more sources