Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage. [PDF]
Retrovirology, 2013 BackgroundLEDGF/p75 (LEDGF) is the main cellular cofactor of HIV-1 integrase (IN). It acts as a tethering factor for IN, and targets the integration of HIV in actively transcribed gene regions of chromatin.
Le Rouzic E +21 more
europepmc +2 more sources
Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase. [PDF]
PLoS ONE, 2007 BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA.
Olivier Delelis +7 more
doaj +2 more sources
The Role of Mesenchymal Stromal Cells in the Treatment of Bronchopulmonary Dysplasia: A Multi-Prong Approach for a Heterogeneous Disease. [PDF]
Compr PhysiolABSTRACT Acute lung injury can be a devastating ailment leading to death in patients of all ages. In preterm neonates, lung injury is unique and unlike what is seen in pediatric and adult populations. The physiology behind the acute lung injury endured in developing lungs and the chronicity of harmful stimuli vastly distinguish how bronchopulmonary ...
Deguise MO, Thébaud B.
europepmc +2 more sources
Twenty-year trends in patient referrals throughout the creation and development of a regional memory clinic network. [PDF]
Alzheimers Dement (N Y), 2020 Abstract Introduction Memory clinics (MCs) are the main model for dementia diagnosis and care. Following the development of a MC network in Northern France, our objectives were to assess its impact on patient characteristics over 20 years. Methods The characteristics of new consultants were studied from 1997 to 2016.
Chen Y +9 more
europepmc +2 more sources
Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo. [PDF]
Antimicrob Agents Chemother, 2010 Delelis O +11 more
europepmc +2 more sources
Description de la performance “BLACKBOOKBLACK”
Relief: Revue Électronique de Littérature Francaise, 2008 Le projet BlackbookBlack consiste notamment à créer un réseau de bibliothèques possédant un livre noir aux pages noires. Le livre, composé de gravures noires, est fabriqué en partie lors de la performance.
Olivier Deprez +2 more
doaj +5 more sources
On the potential of ultrasound elastography for pressure ulcer early detection.
Med Phys, 2011 Deprez JF +4 more
europepmc +2 more sources
Endoscopy, 2021 Main Recommendations 1 ESGE recommends against diagnostic/therapeutic papillectomy when adenoma is not proven. Strong recommendation, low quality evidence. 2 ESGE recommends endoscopic ultrasound and abdominal magnetic resonance cholangiopancreatography (
G. Vanbiervliet +17 more
semanticscholar +1 more source
The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis
FEBS Letters, Volume 597, Issue 12, Page 1623-1637, June 2023., 2023 Using single‐cell RNA‐seq and super‐resolution microscopy from several multiciliogenesis models, we show that BTG4, LAYN, and HOATZ, three proximal genes of the MIR34B/C locus, are expressed in precursors and mature multiciliated cells (MCCs). This graphical abstract illustrates the localization of Layilin/LAYN and HOATZ in motile cilia of MCCs.
Amélie Cavard +15 more
wiley +1 more source
L'humaine mesure ou l'institution des registres catégoriels de l'humain et du non humain [PDF]
, 2019 Which do we conceptualize like Human in opposition to non Human ? The institution of “large shares” or “The Great Divide”, in terms of categories between the Human one and the non Human one, is far from to be always established in various times and Human
Stéphane, Cormier
core +4 more sources