Results 11 to 20 of about 13,122 (200)
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Musicologica Brunensia, 2015 This study consists of the following three parts: Robert Smetana and Bedřich Václavek, coop-eration and personal relationships; Robert Smetana and Olomouc, comparison with the views of Bedřich Václavek; final summary.
Pavlína Kráčmarová
doaj +1 more source
Sustainable two-wheeled mobility in Olomouc: a participatory mapping approach
Journal of MapsUrban mobility is increasingly recognised as central to quality of life, economic vitality, and environmental sustainability. Yet competition for limited urban space often produces tensions between automobility and sustainable transport modes.
Diana Ritterová, Jiří Pánek
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Risk of Severe COVID-19 in Non-Adherent OSA Patients
Patient Preference and Adherence, 2022 Samuel Genzor,1,* Jan Prasko,2– 4,* Jan Mizera,1,* Petr Jakubec,1,* Milan Sova,1,5,* Jakub Vanek,2,* Nikoleta Šurinová,6,* Katerina Langova7,* 1Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky
Genzor S +7 more
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The Management of Sleep Disturbances in Patients with Schizophrenia: A Case Series
Psychology Research and Behavior Management, 2022 Jakub Vanek,1 Jan Prasko,1– 4 Samuel Genzor,5 Jan Mizera5 1Department of Psychiatry, University Hospital Olomouc, Faculty of Medicine, Palacky University in Olomouc, Olomouc, The Czech Republic; 2Department of Psychological Sciences, Faculty of Social ...
Vanek J, Prasko J, Genzor S, Mizera J
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Ve stopách Roberta Smetany aneb Třetí škola české hudební vědy
Musicologica Brunensia, 2015 The credit for the foundation of a musicological institution at the restored university in Olomouc in 1946 goes to Vladimír Helfert's disciple, Robert Smetana (1904–1988). In 1951 he became associate professor and in 1965 professor and was at the head of
Jan Vičar
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Hugo Kołłątaj, a State Prisoner in Olomouc a Josefov in 1794–1802
Poznańskie Studia Slawistyczne, 2018 The Kraków canon priest Hugo Kołłątaj (1750–1812), one of the authors of the Polish Constitution of 3rd May 1791, a writer, philosopher and teacher, the rector of the Jagiellonian University and the Vice-Chancellor of the Polish-Lithuanian Union ...
Marie Sobotková
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Advanced Electronic Materials, EarlyView.Biodegradable wood‐based bioelectronics are realized by integrating poly (2,3‐ethylenedioxythiopene:lignosulfonate (PEDOT:LigS) as a mixed ionicelectronic channel in organic electrochemical transistors fabricated on paper substrates. The biocomposite exhibits high conductivity, biocompatibility, and strong transistor performance, while devices built on
Katharina Matura +8 more
wiley +1 more source
Sleep Disturbance and Immunological Consequences of COVID-19
Patient Preference and Adherence, 2023 Jonas Bocek,1 Jan Prasko,1– 4,* Samuel Genzor,5,* Frantisek Hodny,1,* Jakub Vanek,1,* Pavol Pobeha,6,* Kamila Belohradova,1,* Marie Ociskova1,4,* 1Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky
Bocek J +7 more
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Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, EarlyView.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source