Results 71 to 80 of about 41,764 (197)

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

open access: yesBritish Journal of Haematology, EarlyView.
Trametinib (MEK inhibitor) shows efficacy in refractory and high‐risk adult histiocytic neoplasms. At a median follow‐up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Rodothea Amerikanou   +15 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

open access: yesThe FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén   +11 more
wiley   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

open access: yesHistopathology, EarlyView.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello   +20 more
wiley   +1 more source

PRIMARY LEIOMYOSARCOMA OF THE OMENTUM

open access: yesThe Kurume Medical Journal, 1980
Two cases of leiomyosarcoma developed from great omentum and gastrohepatic omentum respectively are reported. The Case 1 is a 52-year-old female with chief complaint of a mass in the abdomen, which was found to be a primary gastrohepatic tumor upon laparotomy, and histologically diagnosed as leiomyosarcoma.
TANIMURA, AKIRA   +6 more
openaire   +3 more sources

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

open access: yesJournal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag   +6 more
wiley   +1 more source

How I Use the Fourth Arm in Robotic Pancreatoduodenectomy

open access: yes
Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Taisuke Imamura   +7 more
wiley   +1 more source

Reconstruction of deep and perforating corneal defects in dogs—A review (Part II/III): Biomaterials and keratoprosthesis

open access: yesVeterinary Ophthalmology, Volume 28, Issue 2, Page 532-542, March 2025.
Abstract The surgical reconstruction of severe corneal ulcers is a common and crucial component of the clinical practice of veterinary ophthalmology. Numerous surgical techniques are used in dogs for corneal reconstruction, and these techniques may be categorized by the material used to repair the corneal lesion.
Eric C. Ledbetter   +2 more
wiley   +1 more source

Mechanism of Fibrotic Anastomosis Formation in Endoscopic Ultrasound‐guided Hepaticogastrostomy Using a Plastic Stent: Insights From an Autopsy Case of Perihilar Cholangiocarcinoma

open access: yesDEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) is an established alternative to other biliary drainage techniques for treating malignant biliary obstruction. Although the anastomosis created by EUS‐HGS is believed to mature within several weeks, histopathological evidence supporting this assumption remains limited, particularly in ...
Kosuke Maehara   +9 more
wiley   +1 more source

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