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Results 101 to 110 of about 254,235 (292)

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source

Clavis Aurea Thesauri Partheno-Carmelitici, Sive Dissertatio Historico-Theologica, Referans atque Exponens Antiquitatem & originem, confirmationem ac propagationem, beneficia ac privilegia, gratias & indulgentias, munera & obligatione celeberrimae Confraternitatis Scapularis Mariani Dei parae Virginis de monte Carmelo : Per Quam Etiam ... Theologorumq[ue] selectiores opiniones ... declaratur

Authore R.P. Paulo Ab Omnibus Sanctis, Carmelita Excalceato, Provinciae Germaniae DefinitoreVorlageform des Erscheinungsvermerks: Viennæ Austriæ, Typis Matthaei Cosmerovij, Sacræ Caesareæ Majest. Aulæ Typ. Anno Domini 1669.Titelbl.
Paulus
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CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang +6 more
wiley +1 more source

Omnibus Humanus

Delhi Journal of Ophthalmology, 2023
V. S. Gurunadh
doaj +1 more source

2022 NEST Omnibus Survey

Omnibus survey of attitudes and ...
Network for Economic and Social Trends
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Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source

Una pro omnibus, omnes pro una

UNA PRO OMNIBUS, OMNES PRO UNA Una pro omnibus, omnes pro una ( -
Gerhard & Co. G.m.b.H. Berlin
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Berliner Omnibus

BERLINER OMNIBUS Berliner Omnibus (Public ...

core

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang +9 more
wiley +1 more source

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