Results 221 to 230 of about 254,235 (292)

Impact of body mass index on outcomes in acute type A aortic dissection. [PDF]

Front Cardiovasc Med
Kiridly AH, Pupovac SS, Dell'Aquila M, Arnone P, Jarral OA, Tejada B, Mason I, Kalimi R, Scheinerman SJ, Hartman AR, Brinster DR.   +10 more
europepmc   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Environmental Modulation of Perceived Cognitive Workload During a Memory Task: Evidence from Immersive Virtual Reality. [PDF]

J Intell
Orti R, Possenti M, Napolitano LLL, Romano M, Iuliano S, Nunziata S, Silvino AL, Ruotolo F.   +7 more
europepmc   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

TestNet: a method for inferring microbial networks with false discovery rate control for clustered and unclustered samples. [PDF]

Genome Biol
Su C, Mao Y, He M, Van Doren VE, Kelley CF, Hu YJ.   +5 more
europepmc   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Genetically predicted ZDHHC8 expression and osteoporosis risk: A two-sample Mendelian randomization and metabolite mediation study. [PDF]

Medicine (Baltimore)
Yang W, Yang K, Xu S, Yang S.
europepmc   +1 more source

Oral Astilbin Nanogels Modulate Senescence‐Associated CD4+ T Cells and Promote Treg Induction in Aged Mice with Colitis

Advanced Science, EarlyView.
Fluorinated β‐glucan/pectin nanogels enable colon‐targeted oral delivery of astilbin through gastrointestinal protection, β‐glucanase‐responsive release, mucus penetration, and prolonged retention. The released astilbin attenuates senescence‐associated features of CD4+ T cells and promotes Treg responses, while the nanogel matrix modulates the gut ...
Lei Zhao, Xinyun Zhang, Qian Ren, Xue Song, Meifang Zhao, Rongshen Wang, Haocheng Du, Yan Chen, Peigen Xu, Jiangyun Liu, Jian Zhang, Jingjing Ma   +11 more
wiley   +1 more source

Influence of Local Anesthesia Techniques on the Microstructural Integrity of Dental Injection Needles: A Field Emission Scanning Electron Microscopy Analysis. [PDF]

Bioengineering (Basel)
Dervis F, Saruhanoglu A, Ofluoglu D, Koray M.   +3 more
europepmc   +1 more source