Results 71 to 80 of about 1,497,598 (267)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Simulated Galaxy Laboratory: Exploring the Observational Effects on UV Spectral Absorption Line Measurements

The Astrophysical Journal
Ultraviolet absorption line spectroscopy is a sensitive diagnostic for the properties of interstellar and circumgalactic gas. Down-the-barrel observations, where the absorption is measured against the galaxy itself, are commonly used to study feedback ...
R. Michael Jennings, Alaina Henry, Valentin Mauerhofer, Timothy Heckman, Claudia Scarlata, Cody Carr, Xinfeng Xu, Mason Huberty, Simon Gazagnes, Anne E. Jaskot, Jeremy Blaizot, Anne Verhamme, Sophia R. Flury, Alberto Saldana-Lopez, Matthew J. Hayes, Maxime Trebitsch   +15 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

State Estimation-based Transmission line parameter identification

Ingeniería e Investigación, 2010
This article presents two state-estimation-based algorithms for identifying transmission line parameters. The identification technique used simultaneous state-parameter estimation on an artificial power system composed of several copies of the same ...
Fredy Andrés Olarte Dussán, Carlos Eduardo Borda Zapata, Hernando Díaz Morales   +2 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The adductor tubercle can be a radiographic landmark for joint line position determination: an anatomic-radiographic correlation study

Journal of Orthopaedic Surgery and Research, 2019
Background The adductor tubercle (AT) has been used intraoperatively as a landmark to evaluate the joint line position in knee arthroplasty. The purpose of this study was to determine whether the AT could be clearly identified on radiographic imaging as ...
Kuang-Ting Yeh, Ing-Ho Chen, Chen-Chie Wang, Wen-Tien Wu, Kuan-Lin Liu, Cheng-Huan Peng   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Single-phase fault location method for low-resistance grounding system based on zero-sequence voltage distribution

电力工程技术
In low-resistance grounding systems, single-phase ground faults trigger immediate protection tripping. Accurate fault location reduces patrol time and increases the reliability of the power supply. However, time synchronization errors and inaccurate line
Wenhe ZHU, Zhihua ZHANG, Guang LI, Yongduan XUE   +3 more
doaj   +1 more source