Results 141 to 150 of about 2,155,238 (316)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

On-line Monitoring of H310BO3 Preparation from 10BF3

Yuanzineng kexue jishu
The industrial production of H310BO3 (10B>19.8%) requires monitoring the extent of the reaction and determining the endpoint of the reaction. In order to solve the problems of complicated steps, large human error and low accuracy of the existing ...
ZHOU Wenhui1, HU Shilin1, ZHANG Yanbiao1, ZHOU Xiulin2
doaj   +1 more source

Application of Two-Dimensional Fluorescence Spectroscopy for the On-Line Monitoring of Teff-Based Substrate Fermentation Inoculated with Certain Probiotic Bacteria. [PDF]

Foods, 2022
Alemneh ST, Emire SA, Jekle M, Paquet-Durand O, von Wrochem A, Hitzmann B.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

In-Line Monitoring of Downstream Purification Processes for VSV Based SARS-CoV-2 Vaccine Using a Novel Technique. [PDF]

BioTech (Basel), 2021
Makovitzki A, Jayson A, Oren Z, Lerer E, Kafri Y, Dor E, Cherry L, Tzadok H, Levin L, Hazan O, Simon I, Tal A, Girshengorn M, Rosen O.   +13 more
europepmc   +1 more source

NetBem : business equipment energy monitoring through network auditing

, 2010
Presented at the 2nd ACM Workshop On Embedded Sensing Systems For Energy-Efficiency In Buildings (BuildSys 2010), at ACM SenSys 2010, Zurich, Switzerland, November 2, 2010Modern office buildings are fully equipped and furnished spaces with arrangements ...
A. G. Ruzzelli, G. M. P. O'Hare, Ruzzelli, Antonio G., O'Hare, G. M. P. (Greg M. P.), A. Sintoni, Sintoni, Alex, Schoofs, Anthony, A. Schoofs, O\u27Hare, G. M. P. (Greg M. P.)   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Real-time and on-line monitoring of ethanol fermentation process by viable cell sensor and electronic nose. [PDF]

Bioresour Bioprocess, 2021
Feng Y, Tian X, Chen Y, Wang Z, Xia J, Qian J, Zhuang Y, Chu J.   +7 more
europepmc   +1 more source

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring.

, 2009
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from
Sprinz, Eduardo, Egger, Matthias, Wood, R, Tuboi, Suely, Kumarasamy, N, Braitstein, Paula, Kumarasamy, Nagalingeswaran, Schecter, Mauro, Nash, D, Calmy, Alexandra, Brinkhof, Martin W G, Jahn, Andreas, Schechter, M, Boulle, A, Calmy, A, Brinkhof, Martin, Dabis, F, Tweya, Hannock, Brinkhof, Martin, W.G., Keiser, Olivia, MacPhail, Patrick, MacPhail, P, Pujades-Rodriguez, Mar, Tuboi, S, Schechter, Mauro, Nash, Denis, Jahn, A, Braitstein, P, Boulle, Andrew, Dabis, François, Lüthy, R, Keiser, O, Lüthy, Ruedi, Sprinz, E, Tweya, H, Wood, Robin, Pujades-Rodriguez, M   +36 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source