Results 161 to 170 of about 47,819,563 (268)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Extension of earth orbits using low-thrust propulsion
, 2010 The primary motivation for the utilization of space for environmental science, and in-particular Earth Observation, is the unique vantage point which a spacecraft can provide.
Anderson, Pamela, Macdonald, M.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
An extension and numerical analysis of the Hohmann spiral transfer
, 2012 This paper extends previous work on the Hohmann Transfer Spiral (HST) by introducing a plane change into the analysis. An analytical expression determining the critical specific impulse incorporating a plane change is derived for both a circular and ...
Macdonald, Malcolm, Owens, Steven Robert
core
天地一体化信息网络The integration of cross-regional, fragmented edge computing resources is a key aspect in advancing the high-quality development of edge computing infrastructure.
TIAN Lifeng +4 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
2. Space course on low earth orbit transportation. Vol. 1 Proceedings
, 1993 This volume and its companion contains the papers presented during the second Space Course on Low Earth Orbit Transportation held at the Munich University of Technology from October 11-22, 1993.
Technische Univ. Muenchen (Germany)
core
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
A novel approach to hybrid propulsion transfers
, 2011 This paper introduces a hybrid propulsion transfer termed a Hohmann Spiral, incorporating low and high-thrust technologies, analogous to the high-thrust bi-elliptic transfer.
Macdonald, Malcolm, Owens, Steven Robert
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source