Results 231 to 240 of about 5,721,127 (298)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Robust capacity expansion modeling for renewable energy systems. [PDF]

iScience
Kebrich S, Engelhardt F, Franzmann D, Büsing C, Linßen J, Heinrichs H.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Real-world evaluat ion of hybrid Green AI for sustainable and efficient smart supply chain distribution. [PDF]

Sci Rep
Hassouna MA, Aboutabl AE, Diaa NM, Haggag RY.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings. [PDF]

BMC Med
Wang F, Yang J, Yang J, Cheng P, Tan W, Huang D, Zhong M, Liu X, Huang W, Liu Z, Palaniyappan L.   +10 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

On-Demand Chemically Degradable Hydrogels for Biological Applications. [PDF]

Chembiochem
Sheng X, Kim J.
europepmc   +1 more source

Transmission lowers US generation costs, but generator incentives are not aligned. [PDF]

Proc Natl Acad Sci U S A
Ham D, Kay O, Hausman C.
europepmc   +1 more source

A Biobjective Stochastic Model for Intermodal Supply Chains: Application to the Corn and Soybean Flows. [PDF]

Ind Eng Chem Res
Marto M, Chkoniya V, Couto EB, Pinto T, Agra A, Reis MS.   +5 more
europepmc   +1 more source