Results 301 to 310 of about 846,916 (323)
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Human Genetics, 1984
The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized.
K, Willecke, R, Schäfer
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The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized.
K, Willecke, R, Schäfer
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ARE ANTICONVULSANTS ONCOGENIC?
The Lancet, 1974Abstract The duration of treatment with anti-convulsants—i.e., survival-time checked against national death files—and occurrence of neoplasms, ascertained by means of a cancer registry for 1943-67, were determined in 9136 cases of epilepsy admitted to a hospital from 1933 to 1962.
J, Clemmesen +2 more
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Seminars in Musculoskeletal Radiology, 2002
Oncogenic osteomalacia is a rare paraneoplastic syndrome caused by bone and soft tissue tumors. The characteristic clinical, metabolic, and imaging findings are reviewed, as is the radiologist's role in evaluation and diagnosis. New insight into the pathophysiology of oncogenic osteomalacia is also presented.
Kelli Andresen, Edmister +1 more
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Oncogenic osteomalacia is a rare paraneoplastic syndrome caused by bone and soft tissue tumors. The characteristic clinical, metabolic, and imaging findings are reviewed, as is the radiologist's role in evaluation and diagnosis. New insight into the pathophysiology of oncogenic osteomalacia is also presented.
Kelli Andresen, Edmister +1 more
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1998
Virulent strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes induce non-self limiting — neoplastic — growths on susceptible plants, generally in dicotyledonous species from the Angiosperms. In most cases, A. tumefaciens induces unorganized “crown gall” tumors (so named because the growths were often observed at the crown of the plant ...
BINNS A. N., COSTANTINO, Paolo
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Virulent strains of Agrobacterium tumefaciens and Agrobacterium rhizogenes induce non-self limiting — neoplastic — growths on susceptible plants, generally in dicotyledonous species from the Angiosperms. In most cases, A. tumefaciens induces unorganized “crown gall” tumors (so named because the growths were often observed at the crown of the plant ...
BINNS A. N., COSTANTINO, Paolo
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Cancer, 1993
Tumor-suppressor genes (antioncogenes or recessive oncogenes) are cancer genes that achieve their oncogenic effect by mutational inactivation of both normal alleles. By contrast, oncogenes are created from protooncogenes by mutations that lead to aberrant functional activation. Mutation of multiple suppressor genes and/or oncogenes probably is required
R, Bookstein, D C, Allred
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Tumor-suppressor genes (antioncogenes or recessive oncogenes) are cancer genes that achieve their oncogenic effect by mutational inactivation of both normal alleles. By contrast, oncogenes are created from protooncogenes by mutations that lead to aberrant functional activation. Mutation of multiple suppressor genes and/or oncogenes probably is required
R, Bookstein, D C, Allred
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Oncogenes and proto-oncogenes: General concepts
1989Theoretically, the cancerous phenotype of cells can result from epigenetic or biochemical regulatory changes without alteration of the genotype. Although epigenetic changes may contribute to neoplasia, overwhelming evidence supports the concept that neoplasia results from heritable changes allowing unrestrained growth of cells that are associated with ...
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1985
Publisher Summary Oncogenes are a set of cellular and viral genes that induce morphologic transformation and/or neoplastic changes in cells in which they are either activated or introduced in activated form. Their oncogenic properties are defined by the particular cells and biological test systems that are used to detect their presence.
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Publisher Summary Oncogenes are a set of cellular and viral genes that induce morphologic transformation and/or neoplastic changes in cells in which they are either activated or introduced in activated form. Their oncogenic properties are defined by the particular cells and biological test systems that are used to detect their presence.
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Rheumatology, 1989
Rheumatoid arthritis (RA) is probably an auto-immune disorder incited by an infectious insult or primary disorder of the immune system. A viral aetiology is particularly attractive, as not only do we have documented virally associated arthritides in humans, e.g. rubella, Epstein-Barr virus and parvovirus, but also a member of the lentivirus subgroup of
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Rheumatoid arthritis (RA) is probably an auto-immune disorder incited by an infectious insult or primary disorder of the immune system. A viral aetiology is particularly attractive, as not only do we have documented virally associated arthritides in humans, e.g. rubella, Epstein-Barr virus and parvovirus, but also a member of the lentivirus subgroup of
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American Journal of Reproductive Immunology and Microbiology, 1987
ABSTRACT: Early studies designed to investigate the molecular basis of oncogenesis indicated the existence of discrete genes which could cause neoplastic transformation of normal cells in vitro. These genes (which became known as oncogenes) were originally thought to be derived from oncogenic retroviruses and neoplastic transformation was believed to ...
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ABSTRACT: Early studies designed to investigate the molecular basis of oncogenesis indicated the existence of discrete genes which could cause neoplastic transformation of normal cells in vitro. These genes (which became known as oncogenes) were originally thought to be derived from oncogenic retroviruses and neoplastic transformation was believed to ...
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