Results 111 to 120 of about 103,602 (308)
Advanced Science, EarlyView.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
EJC Supplements, 2015 Earlier we showed that at least some of nucleotide sequences with tumor-specific expression are evolutionary novel (reviewed in [A.P. Kozlov, 2014]).
A. Makashov, A. Kozlov
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
A model to investigate the oncogenic activity of MLL-fusions in Acute Myeloid Leukaemia
, 2009 The MLL gene, located on 11q23, is involved in a large number of chromosomal translocations, including t(9;11)(p22;q23) and t(11;19)(p22;q23). These translocations encode the MLL-AF9 and MLL-ENL fusion transcription factors and are prevalent in infant ...
Walf-Voderwüelbecke, V.
core
, 2010 Hematologic malignancies are typically associated with leukemogenic fusion proteins, which are required to maintain the oncogenic state. Previous studies have shown that certain oncogenes that promote solid tumors, such as RAS and BRAF, can induce ...
Wang, Shu-Zong +6 more
core +1 more source
Advanced Science, EarlyView.A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu +8 more
wiley +1 more source
, 2006 The t(10;11)(p13;q14) is a recurring translocation resulting in the fusion of the CALM and AF10 genes. The leukemogenic CALM/AF10 fusion genes codes for a 1595 amino acids protein.
Krause, Alexandre
core
IAPs on the move : role of inhibitors of apoptosis proteins in cell migration
, 2013 Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell
Oberoi-Khanuja, Tripat Kaur +2 more
core +1 more source
Stabilization of Wild-Type MLL Displaces Oncogenic MLL Fusion Proteins [PDF]
Cancer Discovery, 2017 Abstract IL1 signaling promotes degradation of wild-type MLL to enhance MLL leukemia cell proliferation.
openaire +1 more source