Results 311 to 320 of about 369,580 (326)

PROTEIN-PROTEIN INTERACTION NETWORK PERTURBATIONS CAUSED BY ONCOGENIC FUSION EVENTS

144 pages ; Supplemental file(s) description: None. ; Proteins rarely work in isolation but rather function in combinations and complexes. Considering diseases driven by changes at the network level, rather than at the individual protein level has driven the recent development of the strategy of drugging “networks.” My research focuses on gene fusions,
openaire   +2 more sources

Oncogenic mechanisms of fusion proteins in pediatric acute myeloid leukemia

Klinische Pädiatrie, 2023
S Tröster, S Terlecki-Zaniewicz, P Fernandez-Pernas, T Eder, T Humer, J Schmöllerl, G Manhart, J Zuber, E Tomazou, F Grebien   +9 more
openaire   +1 more source

The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins

Leukemia, 1997
N. Uemura, R. Salgia, J-L Li, E. Pisick, M. Sattler, J. Griffin   +5 more
semanticscholar   +1 more source

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer.

Translational Lung Cancer Research, 2015
T. Kohno, T. Nakaoku, K. Tsuta, K. Tsuchihara, S. Matsumoto, K. Yoh, K. Goto   +6 more
semanticscholar   +1 more source

Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands

Nature Cell Biology
Geng Qin, Zhenqi Liu, Jie Yang, Xiaofeng Liao, Chuanqi Zhao, Jinsong Ren, Xiaogang Qu   +6 more
semanticscholar   +1 more source

Companion Diagnostics for Oncogenic Fusion Proteins

2019
Roman Groisberg, Vivek Subbiah
openaire   +1 more source

Combined effects of the two reciprocal t(4;11) fusion proteins MLL·AF4 and AF4·MLL confer resistance to apoptosis, cell cycling capacity and growth transformation

Oncogene, 2007
A. Gaussmann, T. Wenger, I. Eberle, A. Bursen, S. Bracharz, I. Herr, T. Dingermann, R. Marschalek   +7 more
semanticscholar   +1 more source

Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins

Oncogene, 2000
M. Weterman, J. V. Groningen, A. Jansen, A. G. Kessel   +3 more
semanticscholar   +1 more source

Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology

Oncogene, 2004
I. Muyrers-Chen, T. Rozovskaia, Nara Lee, J. Kersey, Tatsuya Nakamura, E. Canaani, R. Paro   +6 more
semanticscholar   +1 more source

Therapeutic Strategies Targeting Oncogenic Fusion Proteins in Sarcomas

Klinische Pädiatrie, 2010
openaire   +1 more source