Results 71 to 80 of about 67,580 (201)

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

Os genes ERCC1 e RRM1 no carcinoma broncopulmonar

Revista Portuguesa de Pneumologia, 2009
Resumo: No cancro do pulmão, ainda não se obteve sobrevivência expressiva dos doentes que se apresentam em estádios não cirúrgicos. Os doentes com carcinoma de não pequenas células são tratados com platina e outros fármacos, para os quais se podem ...
Lina Carvalho, António Silva, Cláudia Andrade, Cláudia Barroso, Cláudia Farinha, José Carlos Fernandes, Raquel Landeiro   +6 more
doaj   +1 more source

Blinatumomab in de novo AYA ALL—Results of the Australasian Leukaemia and Lymphoma Group ALL09 “SUBLIME” study

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Pediatric regimens improve outcomes in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) patients. End‐consolidation (time point 2 [TP2]) minimal residual disease negativity (MRDneg) is associated with improved survival. In this study, standard consolidation chemotherapy was replaced with blinatumomab to improve TP2 MRDneg—a ...
Matthew Greenwood, Shane Gangatharan, Michael Osborn, Ashley P. Ng, Shaun Fleming, Pasquale Fedele, Toby Trahair, John Casey, Sally Mapp, Carol Cheung, Tasman Armytage, Michelle Henderson, Rosemary Sutton, Jacqueline Rehn, Elyse Page, Susan Heatley, Peter Button, Leesa Rowley, Stephen R. Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla Pozza, David Yeung, Deborah White, the Australasian Leukaemia and Lymphoma Group   +26 more
wiley   +1 more source

Oncologia oral: limitações morfológicas e funcionais na reabilitação oral [PDF]

, 2017
O cancro oral está entre os seis tumores malignos mais prevalentes, associado a índices de mortalidade e morbilidade elevados. Os pacientes oncológicos apresentam deterioração de funções básicas devendo-se principalmente ao tratamento exigido.
Silva, Mélanie Mora da
core  

Early suppression of lymphoproliferative response in dogs with natural infection by Leishmania infantum. [PDF]

, 1999
Dogs are the domestic reservoirs of zoonotic visceral leishmaniasis caused by Leishmania infantum. Early detection of canine infections evolving to clinically patent disease may be important to leishmaniasis control.
CIARAMELLA, PAOLO, DE LUNA R., GRADONI L., IELPO M. T. L. AMBROSIO R., MANCINO D., MOSCATIELLO V., PIANTEDOSI, DIEGO, SCALONE A., VUOTTO M. L.   +8 more
core   +1 more source

Venetoclax plus hypomethylating agents as effective bridge therapy to allogeneic stem cell transplant in relapsed/refractory acute myeloid leukaemia: A subanalysis of the AVALON study

British Journal of Haematology, EarlyView.
Elisabetta Petracci, Francesca Pavesi, Luca Castagna, Patrizia Zappasodi, Cristina Papayannidis, Calogero Vetro, Vincenzo Federico, Alessandro Cignetti, Erika Borlenghi, Nicola Fracchiolla, Luca Facchini, Luca Maurillo, Ernesta Audisio, Massimo Bernardi, Felicetto Ferrara, Francesco Lanza, Carmine Selleri, Ilenia Manfra, Claudio Cerchione, Jacopo Nanni, Andrea Davide Romagnoli, Giovanni Marconi, Chiara Zingaretti, Ivana Lotesoriere, Federica Gigli, Giovanni Martinelli, Elisabetta Todisco   +26 more
wiley   +1 more source

TALOs, Fill the Gap: Tafasitamab and Lenalidomide in Diffuse Large B‐Cell Lymphoma in the Real‐Life Patient Journey

Hematological Oncology, Volume 44, Issue 1, January 2026.
ABSTRACT The combination of tafasitamab and lenalidomide (tafa‐lena) has demonstrated efficacy in relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL), as evidenced by the L‐MIND study. To investigate the therapeutic potential and safety profile of tafa‐lena in real‐life, we conducted a national multicentric retrospective study.
Lisa Argnani, Cinzia Pellegrini, Ombretta Annibali, Piera Angelillo, Enrico Amaducci, Filippo Ballerini, Flaminia Bellisario, Andrea Bernardelli, Riccardo Bruna, Catello Califano, Giusy Cetani, Giulia Daghia, Enrico Derenzini, Antonio Frolli, Francesco Gaudio, Valerio Guarente, Ausilia Gorgone, Liardo Eliana Valentina, Elisa Lucchini, Dario Marino, Luca Nassi, Paolo Nicoli, Mattia Novo, Francesca Palombi, Caterina Patti, Vincenzo Pavone, Marcello Riva, Filomena Russo, Greta Scapinello, Alessandro Severino, Monica Tani, Daniele Vallisa, Beatrice Casadei, Alessandro Broccoli, Pier Luigi Zinzani   +34 more
wiley   +1 more source

Linfoma Não-Hodgkin de Alto Grau - Revisão da Literatura

Revista Brasileira de Cancerologia, 2008
Linfomas são transformações neoplásicas de células linfóides normais que residem predominantemente em tecidos linfóides. O linfoma não-Hodgkin (LNH) é a quarta neoplasia mais incidente nos Estados Unidos, excluindo o câncer de pele não-melanoma, e é ...
Luiz Henrique de Lima Araújo, Ana Paula Ornellas de Souza Victorino, Andréia Cristina de Melo, Daniele Xavier Assad, Danilo Silva Lima, Divaldo Rodrigues de Alencar, Melba Moura Lobo Moreira, Otto Metzger Filho, Rafaela de Faria de Souza Coelho, Selem Brandão Asmar, Bruno dos Santos Vilhena Pereira, Adriana Scheliga   +11 more
doaj   +1 more source

Radioembolization of hepatic lesions from a radiobiology and dosimetric perspective

Frontiers in Oncology, 2014
Radioembolization (RE) of liver cancer with 90Y-microspheres has been applied in the last two decades with notable responses and acceptable toxicity. Two types of microspheres are available, glass and resin, the main difference being the activity/sphere.
Marta eCremonesi, Carlo eChiesa, Lidia eStrigari, Mahila eFerrari, Francesca eBotta, Francesco eGuerriero, Concetta eDe Cicco, Guido eBonomo, Franco eOrsi, Chiara Maria Grana, Roberto eOrecchia   +10 more
doaj   +1 more source

Compressão Medular por Tumor de Células Germinativas do Testículo

Acta Médica Portuguesa, 2013
A compressão medular maligna ocorre em 2,5% - 5% dos doentes com cancro. O diagnóstico e intervenção terapêutica urgentes sãofundamentais para o controlo da dor e melhoria dos défices neurológicos.
Fernanda Estevinho, Nuno Sousa, Ângelo Rodrigues, Eduarda Carneiro, João Souto, Rosa Begonha, Joaquina Maurício   +6 more
doaj   +1 more source