Results 51 to 60 of about 67,254 (293)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Efficacy and safety of T-DM1 in the 'common-practice' of HER2+ advanced breast cancer setting: a multicenter study [PDF]

, 2017
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (mBC).
Alesini, Daniele, Arpino, Grazia, Cannita, Katia, Carbognin, Luisa, Caruso, Michele, Cianniello, Daniela, Ciccarese, Mariangela, Cognetti, Francesco, D\u2019Ottavio, Anna Maria, De Laurentiis, Michelino, Fabbri, Agnese, Fabi, Alessandra, Filippelli, Gianfranco, Generali, Daniele, Giampaglia, Marianna, Giannarelli, Diana, La Verde, Nicla, Leonardi, Vita, Montemurro, Filippo, Moscetti, Luca, Paris, Ida, Rossello, Rosalba, Russillo, Michelangelo, Santini, Daniele, Scandurra, Giuseppa, Stani, Simonetta, Valle, Enrichetta, Zambelli, Alberto   +27 more
core   +1 more source

Leukemic Cells Hijack Stromal Bioelectricity to Reprogram the Bone Marrow Niche via CaV1.2‐Dependent Mechanisms

Advanced Science, EarlyView.
Leukemic blasts induce membrane depolarization in mesenchymal stromal cells (MSCs), contributing to a dysfunctional niche that favors leukemia progression. Here, it is demonstrated that restoring the expression of CaV1.2 calcium channel in AML‐MSCs repolarizes their membrane potential, reprogramming them toward a healthy phenotype.
Ambra Da Ros, Maddalena Benetton, Giulia Borella, Giorgia Longo, Giulia Borile, Alice Cani, Diego Lopez‐Pigozzi, Mario Bortolozzi, Silvia Bresolin, Claudia Tregnago, Franco Locatelli, Martina Pigazzi   +11 more
wiley   +1 more source

A non-invasive approach to monitor chronic lymphocytic leukemia engraftment in a xenograft mouse model using ultra-small superparamagnetic iron oxide-magnetic resonance imaging (USPIO-MRI). [PDF]

, 2016
This work was supported by: Associazione Italiana Ricerca sul Cancro (AIRC) [Grant 5 x mille n.9980, (to M.F., F.M. and A. N.)]; AIRC I.G. [n. 14,326 (to M.F.)], [n.10136 and 16,722 (A.N.)], [n.15426 (to F.F.)].
Baio, Gabriella, Basso, Luca, Boccardo, Simona, Calabrese, Massimo, Castronovo, Angela, Cilli, Michele, Cutrona, Giovanna, Emionite, Laura, Fais, Franco, Ferrarini, Manlio, Gentile, Massimo, Massucco, Carlotta, Matis, Serena, Morabito, Fortunato, Neri, Antonino, Neumaier, Carlo Emanuele, Pace, Daniele, Ravina, Marco, Recchia, Anna Grazia, Rosa, Francesca, Salvi, Sandra, Truini, Mauro, Valdora, Francesca   +22 more
core   +2 more sources

Real World Study on the Best CPX‐351 Treatment Duration and Timing for Allogeneic Stem Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT In the registration clinical trial 301 (NCT01696084), CPX‐351 has shown to be superior to conventional 3 + 7 in secondary AML (s‐AML). However, the optimal duration of treatment, the best timing for allogeneic stem cell transplantation (allo‐HSCT), and the activity of CPX‐351 in specific s‐AML subgroups are unclear.
Fabio Guolo, Luana Fianchi, Maria Paola Martelli, Federico Lussana, Francesco Grimaldi, Federica Pilo, Michela Rondoni, Carla Filì, Paola Minetto, Debora Capelli, Patrizia Chiusolo, Massimo Breccia, Sara Mastaglio, Massimo Bernardi, Monica Bocchia, Monica Fumagalli, Sara Galimberti, Valentina Mancini, Anna Lisa Piccioni, Luca Maurillo, Nicola Stefano Fracchiolla, Raffaele Palmieri, Calogero Vetro, Cristina Papayannidis, Lorenzo Brunetti, Alessandra Sperotto, Federica Gigli, Patrizia Zappasodi, Antonino Mulé, Caterina Patti, Erika Borlenghi, Michelina Dargenio, Federica Lessi, Marco Cerrano, Daniela Cilloni, Alessandro Isidori, Monia Lunghi, Caterina Alati, Carmela Gurrieri, Carola Riva, Giovanni Marconi, Ivana Lotesoriere, Samuele Gatani, Anna Maria Scattolin, Manuela Caizzi, Salvatore Perrone, Atto Billio, Filippo Gherlinzoni, Francesco Mannelli, Michele Gottardi, Roberto Cairoli, Anna Candoni, Felicetto Ferrara, Livio Pagano, Roberto Massimo Lemoli, Adriano Venditti, Elisabetta Todisco   +56 more
wiley   +1 more source

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. [PDF]

, 2014
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.
A Kong, A Lomniczi, A Murphy, A Schröder, AA D’Aloisio, Aarno Palotie, AB Migliano, Adamo Pio D’adamo, Aida K. Dieffenbach, AL Dixon, Albert Hofman, Albert V. Smith, Albertine J. Oldehinkel, Alexander Teumer, Alison M. Dunning, Andrea D. Coviello, Andrea Ganna, Andres Metspalu, Andrew C. Heath, Andrew D. Johnson, André G. Uitterlinden, Angela Cox, Anja Rudolph, Anna M. Storniolo, Anna Murray, Anneli Pouta, Annika Lindblom, Antonietta Robino, AP Abreu, Arto Mannermaa, AS Dimas, AV Segrè, B Kabakchiev, B Zhang, BE Stranger, Behrooz Z. Alizadeh, Ben A. Oostra, Bernardo Bonanni, Bjarke Feenstra, BP Fairfax, Bruce H. R. Wolffenbuttel, C Colantuoni, C Liu, C-J Partsch, Carl Blomqvist, Catharina A. Hartman, Cathy E. Elks, CE Elks, Christian Gieger, Chunyan He, CJ Willer, Cornelia M. van Duijn, CP Schaaf, Craig E. Pennell, D Mehta, D Sasayama, DA Cusanovich, Daniel F. Gudbjartsson, Daniel I. Chasman, Daniel L. Koller, David Couper, David J. Hunter, David Karasik, David P. Strachan, David Schlessinger, Debbie Lawlor, Deborah J. Thompson, Diana L. Cousminer, Dieter Flesch-Janys, Diether Lambrechts, Dirkje S. Postma, DM Greenawalt, Doris Stöckl, Dorret I. Boomsma, Douglas F. Easton, Douglas P. Kiel, E Grundberg, E Grundberg, E Grundberg, Eco E. J. de Geus, EE Schadt, EK Speliotes, EL Heinzen, Eleonora Porcu, Elisabeth Widen, Elizabeth A. Streeten, Ellen A. Nohr, Ellen W. Demerath, Emmi Tikkanen, Enda M. Byrne, Eric Boerwinkle, Erik Ingelsson, Erin K. Wagner, Eva Albrecht, Evelin Mihailov, F Innocenti, F Nagl, F Zou, Felix Day, Femke Atsma, Fergus J. Couch, Fernando Rivadeneira, Frank B. Hu, Frank Geller, GA Heap, George Davey Smith, George McMahon, Georgia Chenevix-Trench, Gerard Waeber, Gisli Masson, Gonneke Willemsen, Graham G. Giles, Grant W. Montgomery, Gudmar Thorleifsson, Gudny Eiriksdottir, H Lango Allen, H-J Westra, Harold Snieder, Heather A. Boyd, Heli Nevanlinna, Henri Wallaschofski, Henrik Flyger, Henry Völzke, Hermann Brenner, HHH Göring, Hiltrud Brauch, Hoda Anton-Culver, IK Temple, Ilja M. Nolte, Immaculata De Vivo, Irene L. Andrulis, J Ding, J Huang, J Yang, J Yang, J Yang, J. Margriet Collée, JA Webster, Javier Benitez, JC Barrett, Jenny A. Visser, Jenny Chang-Claude, JF Degner, Jing Hua Zhao, Jinhui Chen, Joanne M. Murabito, Joe Dennis, Johan G. Eriksson, John L. Hopper, John P. Rice, John R. B. Perry, Jonathan Tyrer, Jouke-Jan Hottenga, JR Gibbs, Julia A. Knight, Julian Peto, Julie E. Buring, K Estrada, K Hao, K Michailidou, Kamila Czene, Kari Stefansson, Kathryn L. Lunetta, Katri Pylkäs, Kay-Tee Khaw, Ken K. Ong, KS Kompass, Kyriaki Michailidou, L Liang, Laura Crisponi, Laura J. Bierut, Laura M. Yerges-Armstrong, Lavinia Paternoster, LB Barreiro, LFG Silveira, Lili Milani, Lisette Stolk, Lude Franke, Luigi Ferrucci, Lynda M. Rose, M Horikoshi, M Rantalainen, Maartje J. Hooning, Mads Melbye, Manjeet K. Bolla, Marek Zygmunt, Margaret J. Wright, Marjanka K. Schmidt, Marjo-Riitta Järvelin, Mark I. McCarthy, Massimo Mangino, Matthias W. Beckmann, Meir J. Stampfer, Melanie Waldenberger, Melissa E. Garcia, Mellissa C. Southey, Michael J. Econs, Montserrat García-Closas, Munro Peacock, N Ruf, Najaf Amin, Nancy L. Pedersen, Natalia Tšernikova, Nicholas G. Martin, Nicholas J. Timpson, Nicholas J. Wareham, Nora Franceschini, P Prentice, Paolo Gasparini, Paolo Peterlongo, Paolo Radice, Pascal Guénel, Patrick F. McArdle, Patrick Neven, Patrick Sulem, Patrik K. Magnusson, Paul D. P. Pharoah, Paul M. Ridker, Per Hall, Peter A. Fasching, Peter Devilee, Peter Kraft, Peter Vollenweider, Q Li, Qin Wang, Reedik Mägi, Robert Winqvist, Robin Haring, Roger L. Milne, RP Grinspon, RS Huang, RSN Fehrmann, Ruth J. F. Loos, S Cho, S Constantin, S Sulzbacher, Sandra Lai, Sanela Kjellqvist, SE Parker, Serena Sanna, Sheila Ulivi, Stefania Bandinelli, Stephen Chanock, Stig E. Bojesen, Suiqun Guo, Susan Ring, Sven Bergmann, T Kwan, T Maeda, T Zeller, Tamara B. Harris, Tanguy Corre, Tatiana Foroud, Teresa Ferreira, Thorkild I. A. Sørensen, Tim D. Spector, Tune H. Pers, Tõnu Esko, Ulla Sovio, Unnur Thorsteinsdottir, Ute Hamann, V Emilsson, Veikko Salomaa, Veli-Matti Kosma, Vilmundur Gudnason, W Zheng, Wei Q. Ang, Wendy L. McArdle, Y Idaghdour, Y Stelzer, Z Zadik, Zoltan Kutalik   +271 more
core   +7 more sources

Modulation of Autophagy by Ursolic and Betulinic Acids: Distinct Cytotoxic and Membrane‐Disruption in Malignant and Nonmalignant Cells

Cell Biology International, EarlyView.
ABSTRACT Autophagy is a critical adaptive mechanism in tumor cells that promotes survival under stress, but when dysregulated, it may trigger programmed cell death. The pentacyclic triterpenoids betulinic acid (BA) and ursolic acid (UA) are structurally related compounds that modulate autophagy; however, comparative insights into their effects on ...
Waleska Kerllen Martins, Tayana Mazin Tsubone, Chimara Emilia Nascimento Sanches, Cleidiane de Sousa Rocha, Ricardo Scarparo Navarro, Beatriz Simonsen Stolf, Susana Nogueira Diniz, Rosangela Itri, Mauricio S. Baptista   +8 more
wiley   +1 more source

Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses

International Journal of Cancer, EarlyView.
What's New? Obesity has been linked to the risk of non‐Hodgkin lymphoma (NHL), but the evidence remains inconclusive. Here, the authors investigate the possibility of shared genetic risk factors between obesity and four common NHL types. Drawing on data from 8 genome‐wide association studies, they found that a higher genetically determined BMI was ...
Amy Moore, Eleanor Kane, Lauren R. Teras, Mitchell J. Machiela, Joshua Arias, Orestis A. Panagiotou, Alain Monnereau, Nicole Wong Doo, Zhaoming Wang, Susan L. Slager, Roel C. H. Vermeulen, Claire M. Vajdic, Karin E. Smedby, John J. Spinelli, Joseph Vijai, Graham G. Giles, Brian K. Link, Alan A. Arslan, Alexandra Nieters, Paige M. Bracci, Nicola J. Camp, Gilles Salles, Wendy Cozen, Henrik Hjalgrim, Immaculata De Vivo, Hans‐Olov Adami, Demetrius Albanes, Nikolaus Becker, Yolanda Benavente, Simonetta Bisanzi, Paolo Boffetta, Paul Brennan, Angela R. Brooks‐Wilson, Federico Canzian, Jacqueline Clavel, Lucia Conde, David G. Cox, Karen Curtin, Lenka Foretova, Hervé Ghesquières, Bengt Glimelius, Thomas M. Habermann, Jonathan N. Hofmann, Qing Lan, Mark Liebow, Anne Lincoln, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Lindsay M. Morton, Kari E. North, Kenneth Offit, Marina Padoan, Sara Piro, Alpa V. Patel, Mark P. Purdue, Vignesh Ravichandran, Elio Riboli, Richard K. Severson, Melissa C. Southey, Anthony Staines, Lesley F. Tinker, Ruth C. Travis, Sophia S. Wang, Elisabete Weiderpass, Stephanie Weinstein, Tongzhang Zheng, Stephen J. Chanock, Nathaniel Rothman, Brenda M. Birmann, James R. Cerhan, Sonja I. Berndt   +74 more
wiley   +1 more source

Performance of upper gastrointestinal endoscopy in CDH1 germline pathogenic variant carriers: A multicenter study

International Journal of Cancer, EarlyView.
What's New? Hereditary diffuse gastric cancer, characterized histologically by the presence of signet ring cell carcinoma, is a syndrome primarily caused by pathogenic variants in the CDH1 gene. Preventive strategies include risk‐reducing total gastrectomy and endoscopic surveillance.
Joaquín Castillo‐Iturra, Joan Llach, Irina Luzko, Lara Aguilera, Adrià López‐Fernández, Mara Cruellas, Inmaculada Salces, Maite Herraiz, Virginia Piñol, Gemma Llort, Joaquin Cubiella, Pilar Diez Redondo, Carmen Poves, Fernando Martínez, Ana Guerra, Eduardo Albéniz, Sheyla Montori, Javier Laguna, Anabella Cuestas, Elisa Cantú‐Germano, Antoni Castells, Glòria Fernández‐Esparrach, Francesc Balaguer, Leticia Moreira   +23 more
wiley   +1 more source

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers

EMBO Molecular Medicine, 2017
The cell fate determinant Numb is frequently downregulated in human breast cancers (BCs), resulting in p53 inactivation and an aggressive disease course.
Daniela Tosoni, Sarah Pambianco, Blanche Ekalle Soppo, Silvia Zecchini, Giovanni Bertalot, Giancarlo Pruneri, Giuseppe Viale, Pier Paolo Di Fiore, Salvatore Pece   +8 more
doaj   +1 more source