Results 131 to 140 of about 1,640,336 (314)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

NURSES’ ATTITUDES TOWARD DEATH AND CARING FOR DYING PATIENTS AT MANSOURA ONCOLOGY CENTRE [PDF]

, 2015
Shimaa Elghreeb, Wafaa Ismaiel Shereif Wafaa Ismaiel Shereif, Karima Elshamy   +2 more
openalex   +1 more source

Advancing wide implementation of precision oncology: A liquid nitrogen‐free snap freezer preserves molecular profiles of biological samples [PDF]

, 2023
Hanneke van der Wijngaart, Sahil Jagga, Henk Dekker, Richard de Goeij, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Babs M. Zonderhuis, Harry Holland, Connie R. Jiménez, Henk M.W. Verheul, Srinivas Vanapalli, Mariëtte Labots   +12 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Development of a Joint Tumor Size–Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision‐Making

CPT: Pharmacometrics & Systems Pharmacology
Tumor size–overall survival (TS‐OS) models can support decision‐making in oncology drug development by predicting long‐term OS based on TS data from early data cuts and baseline patient factors.
Herbert Struemper, Chetan Rathi, Morris Muliaditan, Sebastiaan C. Goulooze, Richard C. Franzese, Alejandro Mantero, Murad Melhem, Teun M. Post, Sandra A. G. Visser   +8 more
doaj   +1 more source

Heterogeneous Optimization Framework: Reproducible Preprocessing of Multi-Spectral Clinical MRI for Neuro-Oncology Imaging Research

, 2016
Mikhail Milchenko, Abraham Z. Snyder, Pamela LaMontagne, Joshua S. Shimony, Tammie L.S. Benzinger, Sarah Jost Fouke, Daniel S. Marcus   +6 more
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Expert Consensus of Multidisciplinary Treatment on Bone Metastasis of Prostate Cancer(Version 2020)

Zhongliu Fangzhi Yanjiu, 2020
Prostate Cancer Group, Chinese Anticancer Association Genitourinary Oncology Committee
doaj   +1 more source

PCN345 Understanding the IMPACT of Assessment Frequency on the Study of Adverse Effects (AES) Using Oncology Electronic Health Records (EHRS)

, 2020
Qing‐Man Liang, Q. Zhang, Andrej Rosic, Bryan Bowser, S. Tharani, S. Brake, Kelly Magee, CM Parrinello, Shrujal S. Baxi   +8 more
openalex   +2 more sources