Results 81 to 90 of about 1,640,336 (314)

Large Language Models in Oncology: Revolution or Cause for Concern?

Current Oncology
The technological capability of artificial intelligence (AI) continues to advance with great strength. Recently, the release of large language models has taken the world by storm with concurrent excitement and concern.
Aydin Caglayan, Wojciech Slusarczyk, Rukhshana Dina Rabbani, Aruni Ghose, Vasileios Papadopoulos, Stergios Boussios   +5 more
doaj   +1 more source

Carboplatin is effective therapy for young children with progressiveoptic pathway tumors: A Pediatric Oncology Group phase II study [PDF]

, 2000
Donald H. Mahoney, Michael E. Cohen, Henry S. Friedman, James L. Kepner, Linda S. Gemer, J. William Langston, Hector E. James, Patricia K. Duffner, Larry E. Kun   +8 more
openalex   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

A scenario‐drafting study to explore potential future implementation pathways of circulating tumor DNA testing in oncology

Molecular Oncology
Circulating tumor DNA (ctDNA) detection has multiple promising applications in oncology, but the road toward implementation in clinical practice is unclear.
Astrid Kramer, Carmen Rubio‐Alarcón, Daan van denBroek, Daan C. L. Vessies, Iris van't Erve, Gerrit A. Meijer, Geraldine R. Vink, Ed Schuuring, Remond J. A. Fijneman, Veerle M. H. Coupé, Valesca P. Retèl   +10 more
doaj   +1 more source

Case report: Clinical and genetic features of pediatric choroidal melanoma

Frontiers in Medicine
Uveal melanoma (UM) is the second most common type of primary melanoma in adults, but it is extremely rare in children. We report a 12-year-old boy with a rare juvenile case of UM characterized by specific clinical and genetic features, including eye ...
Paola Valente, Angela Galardi, Angela Di Giannatale, Antonino Romanzo, Antonio Novelli, Valeria Orlando, Marta Colletti, Ida Russo, Rita De Vito, Giancarlo Iarossi, Sergio Petroni, Lorenzo Sinibaldi, Luca Buzzonetti   +12 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Retraction: Frequencies of Porphyromonas gingivalis detection in oral-digestive tract tumors

Pathology and Oncology Research, 2023
Pathology and Oncology Research Editorial Office
doaj   +1 more source

High Dose Progesterone Loaded PCL‐Polysorbate 80 Transdermal Fibers for Potential Application in Gynecological Oncology

Macromolecular Materials and Engineering
Progesterone (P4), commonly administered in high doses for endometrial cancer palliative management, has limitations in current delivery systems. This preliminary in vitro drug release study introduces electrospun patches to offer a new perspective on P4
Omar Shafi, Saurabh Phadnis, Un Hou Chan, Mohan Edirisinghe, Francis Brako   +4 more
doaj   +1 more source

External validation of a novel cancer-associated venous thromboembolism risk assessment score in a safety-net hospital

Research and Practice in Thrombosis and Haemostasis
Background: Cancer-associated thrombosis (CAT) is a leading cause of death in patients diagnosed with cancer. However, pharmacologic thromboprophylaxis use in cancer patients must be carefully evaluated due to a 2-fold increased risk of experiencing a ...
Karlynn N. Dulberger, Jennifer La, Ang Li, Saran Lotfollahzadeh, Asha Jose, Nhan V. Do, Mary T. Brophy, J. Michael Gaziano, Katya Ravid, Vipul C. Chitalia, Nathanael R. Fillmore   +10 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source