Results 231 to 240 of about 29,325 (273)

Risk of malformation after ondansetron in pregnancy: An updated systematic review and meta-analysis.

Birth Defects Research, 2020
Ondansetron is increasingly used off label to treat nausea and vomiting during pregnancy. The main objective of this study was to evaluate the risk of major congenital malformations (MCM), cardiac defects and orofacial clefts associated with first ...
C. Picot, A. Bérard, G. Grenet, E. Ripoche, M. Cucherat, J. Cottin   +5 more
semanticscholar   +1 more source

Comparisons of aprepitant and ondansetron

American Journal of Health-System Pharmacy, 2007
We are responding to the letter from Cavaretta and Noviasky[1][1] concerning Merck’s two Phase III studies of aprepitant 40 mg p.o. versus ondansetron 4 mg (as the hydrochloride salt) i.v. in the prevention of postoperative nausea and vomiting (PONV).[2][2],[3][3] Prophylactic ondansetron ...
Theodore F. Reiss, Christopher Lines, Alexandra D. Carides, Pierre Diemunsch, Bernadette McKeon   +4 more
openaire   +3 more sources

Formation of ondansetron polymorphs

International Journal of Pharmaceutics, 1999
We used differential scanning calorimetry, infrared spectrophotometry and 1H nuclear magnetic resonance imaging to search for polymorphs of ondansetron. Samples were tested under different conditions of temperature, pulverization and pH, and in different solvents.
María Adolfina Ruiz, J. M. Llacer, A. Parera, Visitación Gallardo   +3 more
openaire   +3 more sources

Ondansetron [PDF]

Drugs, 1991
Ondansetron (GR 38032F) is a highly selective 5-HT3 receptor antagonist, one of a new class of compounds which may have several therapeutic applications. Animal and clinical studies show that ondansetron reduces the 24-hour incidence and severity of nausea and vomiting induced by cytotoxic drugs, including cisplatin, and by single exposure, high dose ...
Rennie C. Heel, Richard J. Milne
openaire   +2 more sources

Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects.

Obstetrics and Gynecology, 2018
OBJECTIVE To use data from two large studies of birth defects to describe time trends in ondansetron use for the treatment of first-trimester nausea and vomiting of pregnancy and to investigate associations, either previously reported or undescribed ...
Samantha E. Parker, C. V. Van Bennekom, M. Anderka, A. Mitchell   +3 more
semanticscholar   +1 more source

Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms

Pediatric emergency care, 2018
Objective Ondansetron improves the success of oral rehydration in children with gastroenteritis. In postoperative adults, ondansetron has been shown to prolong the corrected QT (QTc).
Sarah Kline Krammes, T. Jacobs, John M. Clark, R. E. Lutes   +3 more
semanticscholar   +1 more source

Effect of a single dose of i.v. ondansetron on QTc interval in emergency department patients.

American Journal of Health-System Pharmacy, 2018
PURPOSE Results of a study to determine whether i.v. administration of a single dose of 4 mg of ondansetron was associated with QT interval prolongation in emergency department (ED) patients are reported.
Kai Li, Kathy T Vo, Byron K. Lee, N. Addo, Zlatan Coralic   +4 more
semanticscholar   +1 more source

Ondansetron Clinical Pharmacokinetics

Clinical Pharmacokinetics, 1995
Ondansetron is a potent and highly selective serotonin 5-HT3-receptor antagonist which has demonstrated important antiemetic activity and good tolerability in the prevention of chemotherapy-induced nausea and vomiting. Ondansetron is completely and rapidly absorbed from the gastrointestinal tract after oral administration, and does not accumulate with ...
A. Del Favero, F. Roila
openaire   +3 more sources

Ondansetron in acute food protein‐induced enterocolitis syndrome, a retrospective case–control study

Allergy. European Journal of Allergy and Clinical Immunology, 2017
Therapy for moderate to severe acute food protein‐induced enterocolitis syndrome (FPIES) typically consists of intravenous fluids and corticosteroids (traditional therapy). Ondansetron has been suggested as an adjunctive treatment.
S. Sopo, G. Bersani, S. Monaco, G. Cerchiara, Eric Lee, Dianne E. Campbell, Sam Mehr   +6 more
semanticscholar   +1 more source

Ondansetron Use in Pregnancy and Birth Defects: A Systematic Review

Obstetrics and Gynecology, 2016
OBJECTIVE: To examine the risk of birth defects in children born to women who used ondansetron early in pregnancy for nausea and vomiting of pregnancy or hyperemesis gravidarum.
S. Carstairs
semanticscholar   +1 more source