Results 31 to 40 of about 2,965 (259)

One-dimensional electroosmosis consolidation model considering variable saturation

Yantu gongcheng xuebao, 2017
The existing models for electroosmosis are based on the hypothesis of fully saturated soil regime. Variable saturation occurs in the soil regime, thus a new model is expected to improve the calculation accuracy.
ZHOU Ya-dong 1, 2, DENG An 3, LIU Zhong-xian 1, 2, YANG Ai-wu 1, 2, ZHANG Hai 1, 2
doaj   +1 more source

Study on the Creep Behaviors of Interactive Marine-Terrestrial Deposit Soils

Advances in Civil Engineering, 2019
The interactive marine-terrestrial (IMT) deposit soils were formed in the complex depositional environment; their mechanical properties are different from the other deposits.
Zhen Yan, Gang Li, Jinli Zhang, Rui Zhang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

One-dimensional consolidation of unsaturated fine-grained soils

, 1990
In this study, one-dimensional consolidation of fine-grained soils is considered. By taking into account the results of the infiltration theory, a new approach, which is applicable to soils in either saturated or unsaturated conditions, is given.
Haktanir T., Tekinsoy M.A.
core   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Analytical Solutions of Linear Finite-Strain One-Dimensional Consolidation

, 2002
Numerical solutions of linear finite-strain one-dimensional consolidation of both initially unconsolidated and initially fully consolidated soil layers with both one-way and two-way drainage have been available for some time. However, no solutions of the
Morris, P. H.
core   +1 more source

One-dimensional fluid diffusion induced by constant-rate flow injection: Theoretical analysis and application to the determination of fluid permeability and specific storage of a cored rock sample [PDF]

, 2004
We describe the conceptual design and first application of a new method for simultaneously measuring the fluid permeability and specific storage of a rock sample.
Song, I., Odling, N. W., Smyth, N. F., Ngwenya, B. T., Elphick, S. C., Main, I. G.; id_orcid   +5 more
core   +1 more source

Analysis of One-Dimensional Consolidation Considering Non-Darcian Flow Described by Non-Newtonian Index Incorporating Impeded Drainage Boundaries

, 2022
The nonlinear flow law and soil boundaries greatly affect the dissipation process of soil consolidation. Thus, to study the impact of nonlinear flow under impeded drainage boundaries, the classical non-Darcian flow model described by non-Newtonian index ...
Yunbo Wei, Wengui Cao, Huixin Li, Zan Xu, Penglu Cui   +4 more
core   +1 more source