Results 91 to 100 of about 20,866,353 (270)
Health and economic impact of HIV/AIDS on South African households: a cohort study
BMC Public Health, 2003 Background South African households are severely affected by human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) but health and economic impacts have not been quantified in controlled cohort studies.
Booysen Frederick LR, Bachmann Max O
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2022 연구배경 : 전 세계적 추세인 1인가구는 우리나라에서도 빠르게 증가하고 있다. 기존 국내 연구에 따르면 1인가구는 복합만성질환과 정신질환의 비율이 높아 신체 및 정신건강이 취약한 것으로 나타났다. 따라서 본 연구에서 1인가구와 다인가구의 삶의 질을 비교하고자 하였으며 또한 남녀 간에 차이가 있는지 분석하였다. 방법 : 2016–2018년 제7기 국민건강영양조사 원시자료를 이용하여 19세 이상 성인을 연구 대상자로 선정하였고 EQ-5D를 건강관련 삶의
허연, 한송이, 선우성
core
BMC Public Health, 2004 Background The purpose of this study was to determine whether the National Health Interview Survey is a useful source to identify informative families for genetic studies of birth defects. Methods The 1994/1995 National Health Interview Survey (NHIS) was
Nolan Vikki G, Wyszynski Diego F
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sharing, Households and Sustainable Consumption [PDF]
, 2018 Recently, economists and environmental scientists have problematised households, showing that their reducing size in average number of inhabitants has implications for environmental sustainability due to losses in economies of scale.
Yates, Luke
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Financial Policies for Single-Person Household Housing in South Korea
BuildingsWe investigated the determinants of awareness, utilization, and satisfaction regarding financial aid programs for single-person households in South Korea and proposed policy enhancements.
Seran Jeon, Myounghoon Lee, Seiyong Kim
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source