Results 191 to 200 of about 61,395 (261)

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +1 more source

Intramolecular transamidation enables one-pot synthesis of three chiral, Z-shaped perilenediimides for null-type supramolecular polymer formation. [PDF]

Chem Sci
Schwalb AJ, Carreño A, García F, Sánchez L.   +3 more
europepmc   +1 more source

Heterobimetallic Janus Catalysts for the One‐Pot Synthesis of Polar‐Apolar Block Copolymers

Angewandte Chemie, EarlyView.
Heterobimetallic Janus catalysts act as bifunctional initiators, combining two distinct polymerisation mechanisms in one pot to deliver well‐defined apolar‐polar block copolymers. Combining Earth abundant Ti and Al catalysts for respective α‐olefin and lactone polymerisation, the orthogonal activity is enabled by unprecedented initiation from a Ti ...
Raju Chambenahalli, Gary S. Nichol, Jennifer A. Garden   +2 more
wiley   +1 more source

One-Pot Synthesis and Immobilization of Gold Nanoparticles Using Peptidyl Microbeads. [PDF]

Molecules
Yoshida S, Yoshida K, Isozaki T, Oura M, Ozaki M, Tsuruoka T, Usui K.   +6 more
europepmc   +1 more source

Enhancement of Dissymmetry Factors Through Axial Elongation of Hetero[n]helicenes

Angewandte Chemie, EarlyView.
A benzofuran scaffolding strategy enables the synthesis of hetero[9]‐, [12]‐, and [15]helicenes. Structural and chiroptical analyses demonstrate that systematic axial elongation increases helical distortion and significantly amplifies luminescence dissymmetry.
Jeppe S. Mogensen, Christoffer Bræstrup, Christoffer Warming, Georg I. Junker, Yann Lie, Mathias Hermann, Kurt V. Mikkelsen, Michael Pittelkow   +7 more
wiley   +1 more source

One-Pot Synthesis for Doped Amorphous Carbon-Based Compounds: Influence of ZnO Dopant on the Charge Transfer Efficiency. [PDF]

Nanomaterials (Basel)
Vargas-Vidal BA, Baños-López E, Munguía-Fuentes MDR, Hernández-Rodríguez YM, Cigarroa-Mayorga OE.   +4 more
europepmc   +1 more source

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides by a Covalent Catch‐and‐Release Approach

Angewandte Chemie, EarlyView.
A glycan having a hydrazide tag enables chemoenzymatic synthesis of HS oligosaccharides. The hydrazide can, under mild acidic conditions, react with an aldehyde‐containing resin to give an immobilized hydrazone that is stable under neutral conditions, allowing washing. The product can be released by transiminolysis using aqueous hydroxylamine to give a
Francesco Palmieri, Chin Huang, Digantkumar Chapla, Kelley W. Moremen, Geert‐Jan Boons   +4 more
wiley   +1 more source

One-pot synthesis of thermally reversible materials using maleimide-polysaccharide and furan-lignin derivatives. [PDF]

RSC Adv
Silveira V, Papadakis R, Adamopoulos S.
europepmc   +1 more source

Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition

Angewandte Chemie, EarlyView.
A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando, Laora Boulo, Léonid Lavnevich, Elisa Teyssou, Stéphane Marot, Adélie Gothland, Jean‐Michel Guigner, Anne‐Geneviève Marcelin, Mickaël Ménand, Vincent Calvez, Matthieu Sollogoub   +10 more
wiley   +1 more source

A practical one-pot synthesis of dehydroalanine esters. [PDF]

RSC Adv
Shi Q, Zhu M, Liang Z, Dong X, Zhang M, Yang L, Sun P, Xing C, Zha X, Li F, He H, Chen D.   +11 more
europepmc   +1 more source