Results 101 to 110 of about 1,010,293 (299)

Heavy Metal Content in Cigarette and Hookah Tobacco in Iran

open access: yesJournal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Excessive intake of heavy metals has adverse health effects and smoking is one of the sources of these elements. The aim of this study was to investigate the concentrations of 11 heavy metals in tobacco of different widely ...
Mohammad Ali Zazouli   +3 more
doaj  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Calcium and Magnesium in Ilam Drinking Water Sources during 2009-2013 using Geographic Information System (GIS)

open access: yesIranian Journal of Health, Safety and Environment, 2017
Physicochemical quality of water from the acceptability point of view is essential for consumers; protecting the health of consumers and maintenance of water supply systems. The aim of this study is to determine temporal and spatial variations of Calcium
Zabihollah Yousefi   +2 more
doaj  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

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