Results 61 to 70 of about 1,010,293 (299)
Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt+8 more
wiley +1 more source
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao+7 more
wiley +1 more source
A fool's mission? A test of three common assumptions in dental metric analyses
Three aspects of metric variation in the permanent dentition of humans are often simply accepted as true. The first is that formation of the permanent dentition occurs within morphogenetic fields broadly associated with tooth type and jaw.
Brian E. Hemphill
doaj +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
A Statistical Approach in Designing an RF-Based Human Crowd Density Estimation System
The study of human crowd density estimation (H-CDE) using radio frequency is limited due to the nature of wireless medium and the advancement of visual-based systems.
S. Y. Fadhlullah, Widad Ismail
doaj +1 more source
This research aims to analyze relevant factors contributing to the four dimensions of consumer-based brand equity in skin moisturizer industry. It is then followed by the clustering of female consumers of skin moisturizer based on ethnocentrism and ...
Yossy Hanna Garlina
doaj +1 more source
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi+5 more
wiley +1 more source
In this study, the applicability of the Sustainable Forest Management socio-economic functions criterion was investigated together with the forestry studies in Muğla, Isparta and Antalya Regional Directorates of Forestry in the West Mediterranean Region.
Ahmet Tolunay+2 more
doaj +1 more source