Results 31 to 40 of about 25,871,581 (275)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Amplitude-Preserved Wave Equation: An Example to Image the Gas Hydrate System

Energies, 2021
Natural gas hydrate is an important energy source. Therefore, it is extremely important to provide a clear imaging profile to determine its distribution for energy exploration. In view of the problems existing in conventional migration methods, e.g., the
Jiachun You, Sha Song, Umberta Tinivella, Michela Giustiniani, Iván Vargas-Cordero   +4 more
doaj   +1 more source

Exact and Fast Numerical Algorithms for the Stochastic Wave Equation [PDF]

, 2003
On the basis of integral representations we propose fast numerical methods to solve the Cauchy problem for the stochastic wave equation without boundaries and with the Dirichlet boundary conditions.
Martin, A., Prigarin, Sergej M., Winkler, Gerhard, Sergei M. Prigarin, Winkler, G., Martin, Andreas, Prigarin, S.M., Prigarin, Sergej, Andreas Martin, Gerhard Winkler   +9 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

On an efficient approach to solutions of a perturbed nonlinear Schrödinger’s equation

Results in Physics, 2022
The main objective of this paper is to retrieve the analytical solutions for a perturbed nonlinear Schrödinger’s equation. These achievements are obtained by following the basic steps of an efficient approach.
Kamsing Nonlaopon, Shahram Rezapour, Musaad S. Aldhabani, Samirah H. Alsulami, S.K. Elagan   +4 more
doaj   +1 more source

Finite element heterogeneous multiscale methods for the wave equation [PDF]

, 2013
Wave phenomena appear in a wide range of applications such as full-waveform seismic inversion, medical imaging, or composite materials. Often, they are modeled by the acoustic wave equation.
Stohrer, Christian
core   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Using Trajectories in Quantum Cosmology

Universe, 2018
Quantum cosmology based on the Wheeler De Witt equation represents a simple way to implement plausible quantum effects in a gravitational setup. In its minisuperspace version wherein one restricts attention to FLRW metrics with a single scale factor and ...
Patrick Peter
doaj   +1 more source