Results 51 to 60 of about 29,606,773 (297)

Antimicrobial resistance (AMR) in COVID-19 patients: a systematic review and meta-analysis (November 2019–June 2021)

Antimicrobial Resistance and Infection Control, 2022
Background Pneumonia from SARS-CoV-2 is difficult to distinguish from other viral and bacterial etiologies. Broad-spectrum antimicrobials are frequently prescribed to patients hospitalized with COVID-19 which potentially acts as a catalyst for the ...
Ruwandi M. Kariyawasam, Danielle A. Julien, Dana C. Jelinski, Samantha L. Larose, Elissa Rennert-May, John M. Conly, Tanis C. Dingle, Justin Z. Chen, Gregory J. Tyrrell, Paul E. Ronksley, Herman W. Barkema   +10 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

PLoS ONE [PDF]

, 2013
Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of ...
de Witte, Peter A. M., Esguerra, Camila V., Jan Maes, Nadine Bohni (414133), Peter A. M. de Witte (288844), Jean-Luc Wolfender (414138), Sebastian Munck (355816), Maes, Jan, Munck, Sebastian, Nadine Bohni, Camila V Esguerra, Cordero-Maldonado, M. L., Peter A M de Witte, Cordero Maldonado, María Lorena, Siverio Mota, Dany, Appolinary R. Kamuhabwa (355814), Mainen J. Moshi (414137), Bohni, Nadine, Witte, Peter A. M. de, Siverio-Mota, D., Alexander D Crawford, Wolfender, J. L., Laurence Marcourt (414136), Dany Siverio-Mota, Dany Siverio-Mota (414135), de Witte, P.A.M., Maes, J., Cordero-Maldonado, María Lorena, Siverio-Mota, Dany, Marcourt, Laurence, Bohni, N., Kamuhabwa, A.R., Sebastian Munck, Jean-Luc Wolfender, Moshi, M.J., Jan Maes (302360), Appolinary R Kamuhabwa, Moshi, Mainen J., María Lorena Cordero-Maldonado, Munck, S, Esguerra, C.V., Lorena Cordero-Maldonado, Maria, Mainen J Moshi, Crawford, Alexander D., Wolfender, Jean-Luc, María Lorena Cordero-Maldonado (414134), Laurence Marcourt, Crawford, A.D., Kamuhabwa, Appolinary R., Alexander D. Crawford (288845), Camila V. Esguerra (288846), de Witte, Peter A.M., Marcourt, L.   +52 more
core   +1 more source

Molecular surveillance and genetic diversity of Anaplasma spp. in cattle (Bos taurus) and goat (Capra aegagrus hircus) from Hainan island/province, China

BMC Veterinary Research, 2023
Anaplasmosis is a highly prevalent tick-borne intracellular bacterial disease that affects various host species globally, particularly ruminants in tropical and subtropical regions.
Sa Zhou, Liangyuan Huang, Yang Lin, Biswajit Bhowmick, Jianguo Zhao, Chenghong Liao, Qingfeng Guan, Jinhua Wang, Qian Han   +8 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Modeling of malaria vaccine effectiveness on disease burden and drug resistance in 42 African countries

Communications Medicine, 2023
Background The emergence of antimalarial drug resistance poses a major threat to effective malaria treatment and control. This study aims to inform policymakers and vaccine developers on the potential of an effective malaria vaccine in reducing drug ...
Alisa Hamilton, Fardad Haghpanah, Mateusz Hasso-Agopsowicz, Isabel Frost, Gary Lin, Emily Schueller, Eili Klein, Ramanan Laxminarayan   +7 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

A NOTE ON THE ZEROS OF JENSEN POLYNOMIALS

, 2022
Sufficient conditions for the Jensen polynomials of the derivatives of a real entire function to be hyperbolic are obtained. The conditions are given in terms of the growth rate and zero distribution of the function.
Lee, Jungseob, Kim, Young-One
core   +1 more source