Results 251 to 260 of about 5,883,816 (326)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in <i>FGFR2</i>-amplified gastric cancer. [PDF]

Elife
Zhang Y, Wang H, Wei Y, Pan Y, Song X, Shao J, Yu L, Shi T, Wang Y.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

RBM11 drives malignant progression of bladder cancer by regulating GNPDA1-PKM2 axis. [PDF]

iScience
Tong H, Li T, Zhu J, Dou Q, Yu Q, Sun Y, He W.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Enhancing Clinical Workflow Efficiency in Flow Cytometry Reporting with LLMs. [PDF]

J Clin Immunol
Tavolara TE, Meyer J, Garcia C, Kumanovics A, Vanderboom P.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development. [PDF]

Interdiscip Cardiovasc Thorac Surg
Arens J, Belliato M, Broman LM, Clauser JC, Donker DW, Lorusso R, Malfertheiner M, Rajsic S, Swol J, Vercaemst L, Prahl Wittberg L, EACTS Innovation Committee, Section CPB , ECLS & MCS and the EuroELSO Innovation Group .   +13 more
europepmc   +1 more source

An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis. [PDF]

Nat Commun
Thomann S, Hemmer H, Agrawal A, Basu S, Schaf J, Vornberger N, Krammer T, Sagar, Imdahl F, Poth T, Tóth M, Zielinski CE, Poch T, Krause J, Rosenwald A, Breitkopf-Heinlein K, Rahbari N, Grün D.   +17 more
europepmc   +1 more source

Ameliorative effect of selenium nanoparticles combined with post-conditioning on testicular ischemia-reperfusion injury in rats. [PDF]

Sci Rep
Amena-Elmongy, Samy A, Tolba E, Shouman Z, Karrouf G.   +4 more
europepmc   +1 more source