Results 41 to 50 of about 7,692,761 (259)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Real-world evidence couples genomic biomarkers with therapeutic outcomes for canine hemangiosarcoma

Scientific Reports
Splenic hemangiosarcoma (HSA) is a common canine tumor with histology and genetics analogous to human angiosarcoma (AS), a rare and aggressive malignancy arising from vascular cells.
Lucas Rodrigues, Kevin Wu, Garrett Harvey, Gerald Post, Aubrey Miller, Abigail Hull, Lindsay Lambert, Christina Lopes, James Zou   +8 more
doaj   +1 more source

Antibacterial treatment for exotic species, backyard ruminants and small flocks: a narrative review highlighting barriers to effective and appropriate antimicrobial treatment

BMC Veterinary Research, 2022
Antimicrobial resistance is a complex One Health issue that exists in both human and veterinary medicine. To mitigate this ever-growing problem, efforts have been made to develop guidelines for appropriate antimicrobial use (AMU) across sectors.
Dana C. Jelinski, Karin Orsel, J. Scott Weese, John M. Conly, Danielle A. Julien   +4 more
doaj   +1 more source

One health informatics

Proceedings of the 23rd International Conference on World Wide Web, 2014
Zoonoses are a class of infectious diseases causing growing concern of health authorities worldwide. Human and economic costs of zoonoses are substantial, especially in low-resource countries. New zoonoses emerge as a consequence of ecological, demographic, cultural, social and behavioral factors.
openaire   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Attitudes and perceptions of medical doctors towards the local health system: a questionnaire survey in Ecuador

BMC Health Services Research, 2019
Background Health systems worldwide rely on health professionals to deliver services and provide framework structures. Considering their opinions about their work environment, the public policies that regulate their work and the deficiencies of the ...
Esteban Ortiz-Prado, Marta Fors, Aquiles R. Henriquez-Trujillo, Gabriel H. Cevallos-Sierra, Alejandra Barreto-Grimaldos, Katherine Simbaña-Rivera, Lenin Gomez-Barreno, Eduardo Vasconez, Alex Lister   +8 more
doaj   +1 more source

One health, one medicine [PDF]

, 2011
MU offers unmatched opportunities for collaboration in animal and human health. It is Missouri's major public research university with the state's only College of Veterinary Medicine; Colleges of Agriculture, Food and Natural Resources, Engineering and ...
Office of the Provost
core  

Can health trainers make a difference with difficult-to-engage clients? A multisite case study [PDF]

, 2015
A political attempt in the United Kingdom to address health inequalities in the past decade has been the government’s initiative to employ local health trainers (HTs) or health trainer champions (HTCs) to support disadvantaged individuals with aspects of
Barr H., Brooker C., Denness H., Department of Health, Department of Health, DuBrin A. J., Kirkpatrick D. L., Michie S., Morgan A., Preston I., Sirdifield C., South J., Stake R. E, Strauss A., Warr P., White J., Yin R. K.   +16 more
core   +1 more source

One health in history. [PDF]

, 2015
Abstract This chapter outlines the history of One Health. The first section of the chapter analyses intersections between human and animal health in the premodern era, to reveal how deeply animals and animal health were embedded within human medicine.
Michael Bresalier, Angela Cassidy, Abigail Woods   +2 more
openaire   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source