Results 191 to 200 of about 483,490 (249)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Farm Atmosphere: Calm Attention and Mobility Characterise Positive Horse Welfare. [PDF]

Animals (Basel)
Hausberger M, Lerch N, Grandgeorge M.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

An Investigation of Shelter Workers' Perspectives on the Assessment and Management of Unowned Cat Welfare in the United Kingdom. [PDF]

Animals (Basel)
Bhatia A, Barcelos AM, McDonald JL, Waterman J, Finka L.   +4 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

CRISPR mediated PRRS resistant pigs: biological success, welfare implications, and ethical regulatory challenges for sustainable swine production. [PDF]

Porcine Health Manag
Khan S, Korai Z, Korai SK, Li S, Yang L, Ahmed S, Mirvasif S, Kholmatov A, Amirov A, Xolov S, Shah MA, Wang X.   +11 more
europepmc   +1 more source

Framing a pig welfare assessment protocol suitable for smallholder settings in low-to-middle income countries. [PDF]

Trop Anim Health Prod
Oehlers L, Doyle R, Glatz PC, Toribio JA.   +3 more
europepmc   +1 more source

Corporate Welfare and Parenting Self-Regulation as Protective Resources Against Stress and Quiet Quitting: A Moderated Mediation Model Across Mothers and Fathers. [PDF]

Behav Sci (Basel)
Rapisarda S, Girardi D, Pileri J, Falco A, Dal Corso L.   +4 more
europepmc   +1 more source