Results 81 to 90 of about 16,870 (170)

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

<i>APOE</i> and <i>CCR2</i>: Potential Macrophage-Specific Biomarkers in the Rheumatoid Arthritis Synovial Microenvironment Identified by Bioinformatics and Experimental Verification in Murine Models. [PDF]

J Inflamm Res
Wang D, Lu L, Zhang Y, Shang W.
europepmc   +1 more source

A Review of Failure Modes and Safety Strategies of Lithium‐Ion Batteries from Materials to Systems

Advanced Science, EarlyView.
A cascade‐aware framework is presented for lithium‐ion battery safety, linking thermal runaway initiation, acceleration, runaway reaction, and propagation with material‐, cell/pack‐, and system‐level interventions. By integrating failure mechanisms, quantitative safety indicators, and staged interception strategies, this review highlights how safer ...
Jin Hyeok Yang, Jae Yoon Sung, Hyunji Kweon, Seohyun Kim, Byunghoon Kim, Jongsoon Kim, Junyoung Mun, Jung Ho Kim, Ki Jae Kim   +8 more
wiley   +1 more source

Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram. [PDF]

Nat Commun
Zheng CX, Palit S, Venezia M, Blum E, Pedmale UV, Jackson D, Scarpella E, Prusinkiewicz P, Navlakha S.   +8 more
europepmc   +1 more source

Interfacial Control in Cu–MXene Hybrids Enables Selective NOx‐to‐NH3 Electroconversion: A Critical Review

Advanced Science, EarlyView.
Cu‐MXene interfacial catalysts provide a promising platform for electrochemical NOx upcycling to ammonia. The synergy between Cu active sites and conductive, surface‐tunable MXene supports promotes NOx adsorption, intermediate stabilization, and selective NH3 formation while suppressing competing hydrogen evolution, offering a route toward sustainable ...
Hafiz Muhammad Adeel Sharif, Gechuanqi Pan, Yuwei Wang, Yasir Abbas, Asif Mahmood, Changping Li   +5 more
wiley   +1 more source

Complex interactions among soil physicochemical interactions and microbial community associations with potato common scab severity. [PDF]

Front Plant Sci
Gyeryeong B, Jeom-Soon K, Jeong-Tae L, Yang-Min K.   +3 more
europepmc   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Building causal models in pain research: the case of executive functioning and transitions in pain states. [PDF]

Pain
De Paepe AL, Gibby A, Oporto-Lisboa L, Ehrhardt B, Nunes M, Fisher E, Keogh E, Eccleston C, Woolley C, McBeth J, Crombez G.   +10 more
europepmc   +1 more source

A Multimodal Haptic Feedback Interface with Thin‐Film Compliant Mechanism

Advanced Science, EarlyView.
Multimodal haptic devices can trigger different mechanoreceptors, enabling richer haptic information. This study presents an electromagnetic multimodal haptic device capable of delivering indentation, stretch, and vibration stimuli. The device is enabled by a novel polymer thin‐film compliant mechanism that provides high translational compliance along ...
Jingjing Wan, Emanuele Nicotra, James Davies, Kefan Zhu, Quang Anh Nguyen, Sinuo Zhao, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Hermione Truong, Patrick Pruscino, Tan Huynh, Phuoc Thien Phan, Hoang‐Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do   +15 more
wiley   +1 more source

Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export. [PDF]

EMBO J
Wang X, Hu Y, Liu L, Huang R, Wang Y, Liu B, Zhao Y, Zhu Y, Lv J, Liu L, Wang H, Wu L, Xu X, Li Y, Wang G, Chen XW.   +15 more
europepmc   +1 more source