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Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu +12 more
wiley +1 more source
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Journal of Environmental and Agricultural Studies, 2023
As the largest coal exporting country in the world, Indonesia needs efforts to prevent various negative things for coal mining activities to maintain the balance of the surrounding nature. One of the many affected by mining activities is water. The wastewater quality must be checked regularly before it flows into water bodies.
Deden Disa Abdullah +9 more
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As the largest coal exporting country in the world, Indonesia needs efforts to prevent various negative things for coal mining activities to maintain the balance of the surrounding nature. One of the many affected by mining activities is water. The wastewater quality must be checked regularly before it flows into water bodies.
Deden Disa Abdullah +9 more
openaire +1 more source
Polymerization Online Monitoring
Chemical Engineering & Technology, 2010AbstractOnline monitoring of polymerization reactions is not only important due to the high exothermic nature of most polymerization systems; the data gained also provides information on product composition and quality and control possibilities thereof. Many inline and online methods are still in development and are better suited for application on the
E. Frauendorfer +2 more
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Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1998
Abstract The FINUDA online monitoring system is based on an object oriented approach in the framework of the ROOT package, recently developed at CERN. The Raw Data Tape is re-organized into a Hit Data Tape. The HDT event is structured as a tree of hits available as objects, easily correlated to each other by dedicated ROOT macros.
P Cerello, V Filippini
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Abstract The FINUDA online monitoring system is based on an object oriented approach in the framework of the ROOT package, recently developed at CERN. The Raw Data Tape is re-organized into a Hit Data Tape. The HDT event is structured as a tree of hits available as objects, easily correlated to each other by dedicated ROOT macros.
P Cerello, V Filippini
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2020
This chapter shows that temperature measurement yields valuable bulk indications of the condition of an electrical machine using simple sensors and narrow bandwidth (
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This chapter shows that temperature measurement yields valuable bulk indications of the condition of an electrical machine using simple sensors and narrow bandwidth (
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Online NMR for monitoring biocatalysed reactions
Current Opinion in Biotechnology, 2000Monitoring biocatalysed reactions and metabolic pathways using NMR spectroscopy is of growing interest. As a non-invasive analytical method providing simultaneous information about intracellular and extracellular constituents, it is superior to other analytical techniques and has a wide range of applications: kinetics and stoichiometrics of metabolic ...
Weber, Hansjörg, Brecker, Lothar
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Medical economics, 2001
New disease management programs are enabling physicians to do just that. Can this help you improve care, or is it just another boondoggle?
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New disease management programs are enabling physicians to do just that. Can this help you improve care, or is it just another boondoggle?
openaire +1 more source
Online circuit reliability monitoring
Proceedings of the 19th ACM Great Lakes symposium on VLSI, 2009In this work we propose an online reliability tracking framework that utilizes a hybrid network of on-chip temperature and delay sensors together with a circuit reliability macromodel. We are concerned specifically with NBTI-induced transistor aging, which manifests itself as the gradual increase of PMOS threshold voltage and increase of circuit delay ...
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