Results 251 to 260 of about 2,420,876 (301)
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Online monitoring of phytate content in plant residuals during wet-treatment. [PDF]
Sci RepWidderich N, Bubenheim P, Liese A.
europepmc +1 more source
DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy
Advanced Science, EarlyView.Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi +12 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Online monitoring technology for deep phenotyping of cognitive impairment after stroke
Gruia D +8 more
europepmc +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems
Advanced Science, EarlyView.Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen +8 more
wiley +1 more source
Internet of things-based study on online monitoring system of building equipment energy saving optimization control using building information modeling. [PDF]
Sci ProgXie D, Xie Q.
europepmc +1 more source
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Journal of Environmental and Agricultural Studies, 2023
As the largest coal exporting country in the world, Indonesia needs efforts to prevent various negative things for coal mining activities to maintain the balance of the surrounding nature. One of the many affected by mining activities is water. The wastewater quality must be checked regularly before it flows into water bodies.
Deden Disa Abdullah +9 more
openaire +1 more source
As the largest coal exporting country in the world, Indonesia needs efforts to prevent various negative things for coal mining activities to maintain the balance of the surrounding nature. One of the many affected by mining activities is water. The wastewater quality must be checked regularly before it flows into water bodies.
Deden Disa Abdullah +9 more
openaire +1 more source