Results 41 to 50 of about 1,659,573 (277)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Faulty Metrics and the Future of Digital Journalism [PDF]
, 2010 This report explores the industry of Internet measurement and its impact on news organizations working online. It investigates this landscape through a combination of documentary research and interviews with measurement companies, trade groups ...
John Kelly, Lucas Graves
core
Leveraging online news for language learning across diverse educational contexts
Literacy Trek, 2023 Digitization has made the news accessible to many people worldwide. Since it contains large quantities of authentic language input, online news has riveted language learners, teachers, and educators.
İbrahim Halil Topal
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Systems, 2023 This paper contributes to the Special Issue on Communication for the Digital Media Age by investigating the factors that influence the management of political information on online news media platforms, specifically Twitter and Weibo.
Xiaohong Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Modeling and predicting the popularity of online news based on temporal and content-related features [PDF]
, 2017 As the market of globally available online news is large and still growing, there is a strong competition between online publishers in order to reach the largest possible audience.
Demeester, Thomas +3 more
core +1 more source
Misinformation Concerns and Online News Participation among internet Users in India
Social Media + Society, 2021 The rise of misinformation often circulated in various social media platforms has not only raised concerns among the policymakers and civil society groups, but also among citizens.
Taberez Ahmed Neyazi +2 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source