Results 221 to 230 of about 11,071,611 (300)

An easy-to-use three-dimensional protein-structure-prediction online platform "DPL3D" based on deep learning algorithms. [PDF]

Curr Res Struct Biol
Gao Y, Wang H, Zhou J, Yang Y.
europepmc   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Community case study: Our Wave, an online platform to facilitate survivor disclosure of sexual assault and trauma recovery. [PDF]

Front Public Health
Sinko L, Naidenko OV, Michaelsen B, Marzke C, Hart M, Tweedie B, Linton K.   +6 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Testing Different Message Styles about Unnecessary Antibiotics Using an Online Platform. [PDF]

Antibiotics (Basel)
Stenlund S, Appelt KC, Ruby MB, Smith N, Lishman H, Patrick DM.   +5 more
europepmc   +1 more source

Online learning Platform

Online learning ...
openaire   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

PROSCA: an online platform for humanized scaffold mining facilitating rational protein engineering. [PDF]

Nucleic Acids Res
Wang X, Zhang Y, Li Z, Duan Z, Guo M, Wang Z, Zhu F, Xue W.   +7 more
europepmc   +1 more source

Online collaborative platform

online collaborative web-based tool to exchange project document, monitor the project workflow, send ...
openaire   +1 more source