Results 41 to 50 of about 1,120,696 (275)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Perceptions of medical students towards online teaching during the COVID-19 pandemic: a national cross-sectional survey of 2721 UK medical students

BMJ Open, 2020
Objectives To investigate perceptions of medical students on the role of online teaching in facilitating medical education during the COVID-19 pandemic.Design Cross-sectional, online national survey.Setting Responses collected online from 4th May 2020 to
Samiullah Dost, Aleena Hossain, Mai Shehab, Aida Abdelwahed, Lana Al-Nusair   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Debiasing Desire: Addressing Bias & Discrimination on Intimate Platforms

, 2018
Designing technical systems to be resistant to bias and discrimination represents vital new terrain for researchers, policymakers, and the anti-discrimination project more broadly.
Barocas, Solon, Hutson, Jevan, Levy, Karen, Taft, Jessie G.   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Covid-19 and the Information Crisis of Liberal Democracies: Insights from Anti-Disinformation Action in Italy and EU

Partecipazione e Conflitto, 2021
Action against disinformation has become more important than ever in the context of the Covid-19 pandemic. This is due to the synchronous global scale of the problem and its potentially deadlier consequences as the public seeks out guidance regarding ...
Fabrizio Di Mascio, Michele Barbieri, Alessandro Natalini, Donatella Selva   +3 more
doaj   +1 more source

Wreading on Online Literature Platforms

Written Communication, 2022
Millions of users write and read freely accessible texts every day on online literary platforms (OLPs). Intra-platform surveys aside, only very few studies have considered the demographics of digital readers and authors. Our exploratory study of avid OLP users helps to close this research gap.
Kraxenberger, Maria, Lauer, Gerhard
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Population Activities on Online Labor Market Platforms

Вестник Кемеровского государственного университета. Серия: политические, социологические и экономические науки
As more and more people turn to online labor market platforms, their behavior patterns seem to depend on certain national factors. This research compared the activity patterns demonstrated by different populations on online labor markets, i.e., dynamics,
Galieva Gul'naz, Alehina Ol'ga, Koryakina Tat'yana, Bashlykov Timofey   +3 more
doaj   +1 more source