Results 121 to 130 of about 16,235,545 (254)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo   +10 more
wiley   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

open access: yesAdvanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo   +11 more
wiley   +1 more source

Structural Divergence Between the Moltbook AI‐Agent Network and Human Social Networks

open access: yesAdvanced Science, EarlyView.
Analysis of the Moltbook AI‐agent network reveals a striking combination of familiar global scaling and distinct internal organization. Attention is highly concentrated, reciprocity is limited, connected triads are suppressed, and communities are strongly modular.
Wenpin Hou, Zhicheng Ji
wiley   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

open access: yesAdvanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen   +11 more
wiley   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

open access: yesAdvanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang   +5 more
wiley   +1 more source

Percepções de interatividade e tecnologia no processo de tutoria do FGV Online

open access: yes, 2012
This paper aims to present and discuss the interactivity and technology in the process of mentoring in the Distance Learning Program Online FGV, focusing the discussion on the impacts of this process in the construction of students' knowledge.
Amaral, Rita
core  

Index 1958 [PDF]

open access: yes, 1958
This is the College of Wooster Index from 1958. At the beginning of the Index is a dedication to Dr. Warren P. Spencer, a professor at the college, in Recognition of his Invaluable Service to the Community of the Wooster Campus. Next, is the section of
Editors, Index
core  

SPICE‐Compatible Compact Modeling of Cuprate‐Based Memristors Across a Wide Temperature Range

open access: yesAdvanced Electronic Materials, EarlyView.
A physics‐guided compact model for YBCO memristors is introduced, incorporating carrier trapping, field‐induced detrapping, and a differential balance equation to describe their switching dynamics. The model is compared with experiments and implemented in LTspice, allowing realistic circuit‐level simulations.
Thomas Günkel   +6 more
wiley   +1 more source

Children worldwide gain benefits, face risks online

open access: yes, 2016
A majority of children say they learn something new online at least every week, but large numbers still face risks online, according to the Global Kids Online Research Synthesis Report 2015 – 2016 produced by the UNICEF Office of Research – Innocenti and
Global Kids Online
core  

Declarative rule-based integration and mediation for XML data in web service-based software architectures [PDF]

open access: yes, 2007
The Application Service Provider (ASP) has started to use Web services to expose data sources and adopted Service Oriented Architecture (SOA) to build data integration infrastructure. XML data integration and mediation in SOA is a complex task.
Zhu, Yaoling
core  

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