Results 71 to 80 of about 660,980 (268)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Consumer Expectations for Cream Cheese: A Category Appraisal Study in the United Kingdom with Dairy and Plant-Based Variants in Various Flavours

Foods
The purpose of the present research was to deliver new knowledge of consumer expectations for plant-based (PB) alternatives to cream cheese (PBCCA) by conducting a category appraisal study.
Sara R. Jaeger, Sok L. Chheang, Joachim J. Schouteten   +2 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A Pre-Post Survey Analysis on Pharmacy Students' Perceptions of Pharmacist Roles in the Pharmaceutical Industry

Borneo Journal of Pharmacy
The pharmaceutical industry is undergoing rapid evolution, characterized by a complex regulatory landscape and the need for diverse skill sets. This study aimed to assess pharmacy students’ perceptions of the pharmaceutical industry and the impact of a ...
Anugerah Budipratama Adina, Alhara Yuwanda, Rizky Farmasita Budiastuti, Nopratilova Nopratilova, Eddy Yusuf, Suk Fei Tan, Saeid Mezail Mawazi, Amelia Herli   +7 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Stakeholders' views on the global guidelines for the sustainable use of non‐native trees

People and Nature
A large number of non‐native trees (NNTs) have been introduced globally and widely planted, contributing significantly to the world's economy. Although some of these species present a limited risk of spreading beyond their planting sites, a growing ...
Ana Novoa, Giovanni Vimercati, Giuseppe Brundu, David M. Richardson, Urs Schaffner, Antonio Brunori, Thomas Campagnaro, Susan Canavan, Laura Celesti‐Grapow, Michele Dechoum, Katharina Dehnen‐Schmutz, Jean‐Marc Dufour‐Dror, Franz Essl, S. Luke Flory, Heinke Jäger, Jasmin Joshi, Marion Karmann, Barbara Langdon, Katharina Lapin, Johannes Le Roux, Vanessa Lozano, Mauro Masiero, Laura A. Meyerson, Martin A. Nuñez, Aníbal Pauchard, Jan Pergl, Annabel J. Porté, Petr Pyšek, Jana Pyšková, Jonatan Rodriguez, Ross T. Shackleton, Joaquim S. Silva, Tommaso Sitzia, Laura Verbrugge, Michaela Vítková, Yitbarek Tibebe Weldesemaet, Marjana Westergren, John R. U. Wilson   +37 more
doaj   +1 more source

The Savvy Survey #13: Online Surveys

EDIS, 2013
As part of the Savvy Survey Series, this publication provides Extension faculty with an overview of the process that uses email to invite participants to complete an on-line survey. This 10-page fact sheet provides guidance for constructing an online questionnaire, addressing visual design and formatting considerations, and implementing an online ...
Glenn D. Israel, Jessica L. Gouldthorpe
openaire   +5 more sources