Results 101 to 110 of about 406,468 (271)

HTAP benchmark in financial scenarios

open access: yesSecurity and Safety
With the development of HTAP (Hybrid Transactional/Analytical Processing), the use of HTAP databases has become increasingly common. HTAP databases integrate OLTP (Online Transaction Processing) and OLAP (Online Analytical Processing) into a single ...
Wu Weilong   +6 more
doaj   +1 more source

One‐Step Copper‐Assisted Synthesis of α‐(Styrylsulfonyl)amides via SO2 Incorporation Under Visible Light

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
α‐(Styrylsulfonyl)amides are prepared from α‐bromoamides, SO2, and styrenes in a one‐step photoredox‐catalyzed reaction in the presence of a copper complex. Additionally, related ester analogs could be synthesized following the same procedure. The mechanism of the newly developed method is investigated and model postmodification reactions are carried ...
Nejc Petek, Till Opatz
wiley   +1 more source

Zinc Hydride Complexes Stabilized by Anionic N‐Heterocyclic Carbenes for Hydrosilylation of Aldehydes and Ketones

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Neutral zinc hydride complexes supported by anionic N‐heterocyclic carbene (NHC) ligands containing a weakly coordinating borate anion (WCA‐NHC) are synthesized and structurally characterized. The dimeric and monomeric zinc hydrides act as efficient catalysts for the hydrosilylation of aldehydes and ketones, highlighting solvent‐dependent aggregation ...
Zeinab Hosseinpour   +3 more
wiley   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

open access: yesAdvanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack   +13 more
wiley   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

open access: yesAdvanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen   +31 more
wiley   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

open access: yesAdvanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang   +15 more
wiley   +1 more source

Continuous Physics‐Informed Learning Expedited Battery Mechanism Decoupling

open access: yesAdvanced Science, EarlyView.
A battery modeling framework combining dual neural networks with physical prior is presented to track internal mechanisms, decouple overpotential components, and early predict aging trajectories using only DC data, eliminating the need for additional measurements.
Shanling Ji   +7 more
wiley   +1 more source

Integrating Single‐Cell Transcriptome‐Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune‐Related Drug Targets for Cancers

open access: yesAdvanced Science, EarlyView.
Inspired by evidence triangulation, a new sensitivity method called MR‐DEG is developed, which uses the differentially expressed gene (DEG) results as additional evidence to minimize pleiotropic effects and strengthen Mendelian randomization (MR) causal estimates. Using dynamic single‐cell expression quantitative trait loci (eQTLs) as an example, it is
Jie Zheng   +29 more
wiley   +1 more source

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