Results 11 to 20 of about 10,932 (172)

An Implementation of Deep Reinforcement Learning‐Based Routing Framework for Open‐Network Operating System‐Controlled and Mininet‐Emulated Software‐Defined Networking

IET Networks
Coping with the unprecedented surge in traffic volume necessitates a profound overhaul of traditional networking architectures. In response, software‐defined networking (SDN) has emerged as a groundbreaking architecture that separates the control plane ...
Marwa Kandil Mohammed, Mohamad Khattar Awad, Eiman Mohammed Alotaibi, Reza Mohammadi   +3 more
doaj   +2 more sources

Flexible open network operating system architecture for implementing higher scalability using disaggregated software‐defined optical networking

IET Networks
The enhanced capacity of optical networks is a significant advantage within the global telecommunications industry. Optical networks provides transmission of information over large distances with reduced latency. However, the growing intricacy of network
Kenneth Nsafoa‐Yeboah, Eric Tutu Tchao, Benjamin Kommey, Andrew Selasi Agbemenu, Griffith Selorm Klogo, Nana Kwadwo Akrasi‐Mensah   +5 more
doaj   +2 more sources

Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research. [PDF]

Alzheimers Dement
Abstract The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address training gaps in preclinical translational studies for Alzheimer's disease (AD).
Sasner M, Onos KD, Territo PR, Sukoff Rizzo SJ.   +3 more
europepmc   +2 more sources

Agreement Between Dried Blood Spot and Plasma PCR in Infants With Congenital Cytomegalovirus Infection. [PDF]

J Med Virol
ABSTRACT Congenital cytomegalovirus (cCMV) infection is diagnosed by positive urine or saliva testing within 21 days after birth. Beyond this age, newborn dried blood spot (DBS) PCR can retrospectively diagnose cCMV infection but has lower sensitivity than urine or saliva PCR testing.
Shimamura M, Kim J, Medoro AK, Flint K, Kaptsan I, Wang H, Pifer T, Harris R, Cuartas J, Leber A, Sánchez PJ.   +10 more
europepmc   +2 more sources

Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction. [PDF]

Alzheimers Dement
Abstract BACKGROUND Alzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein Eε4 (APOEε4) being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection.
Onos KD, Lin PB, Pandey RS, Persohn SA, Burton CP, Miner EW, Eldridge K, Kanyinda JN, Foley KE, Carter GW, Howell GR, Territo PR.   +11 more
europepmc   +2 more sources

Deciphering Microglial Contributions to Amyloid and Tau Pathology in Diverse Genetic Contexts [PDF]

Alzheimers Dement
Abstract Background There is strong evidence that underlying genetics of an individual can significantly modify response to development of amyloid and tau pathology with age. Genome‐wide association studies indicate that variation in more than 25 genetic loci relevant to microglial biology are predicted to increase susceptibility to Alzheimer’s disease
Onos K, Keezer K, Perkins B, Perkins A, Oblak A, Howell G.   +5 more
europepmc   +2 more sources

Identifying genetic risk factors driving cerebral amyloid angiopathy using novel mouse models [PDF]

Alzheimers Dement
Abstract Background Cerebral amyloid angiopathy (CAA) co‐occurs with neurodegeneration in Alzheimer’s disease (AD). CAA is absent in many AD mouse models, rendering CAA difficult to study. Previous work has shown wild‐derived WSB/EiJ (WSB) mice over‐expressing APP/PS1 had increased CAA, and thus may be useful in investigating CAA‐causing mechanisms ...
Marola O, Onos K, Diemler C, Keezer K, Sasner M, Howell G.   +5 more
europepmc   +2 more sources

Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits. [PDF]

Aging Cell
Projection neurons from distinct excitatory circuits were labeled in young, middle‐aged and aged mice from two genetically distinct strains exhibiting diverging susceptibility to cognitive aging. Analyses of dendritic spines show C57BL/6J mice that are susceptible to cognitive aging lose excitatory prefrontal cortex (PFC) spines while maintaining CA1 ...
Heuer SE, Nickerson EW, Howell GR, Bloss EB.   +3 more
europepmc   +2 more sources

Towards Crossfire Distributed Denial of Service Attack Protection Using Intent-Based Moving Target Defense Over Software-Defined Networking

IEEE Access, 2021
Crossfire is an indirect target area link-flooding Distributed Denial of Service (DDoS) attack determined to affect the neighbors of the real target.
Muhammad Faraz Hyder, Tasbiha Fatima
doaj   +1 more source

The Role of Inter-Controller Traffic for Placement of Distributed SDN Controllers [PDF]

, 2016
We consider a distributed Software Defined Networking (SDN) architecture adopting a cluster of multiple controllers to improve network performance and reliability.
Bianco, Andrea, De Domenico, Samuele, Giaccone, Paolo, Zhang, Tianzhu   +3 more
core   +2 more sources