Results 101 to 110 of about 1,382,662 (294)

AdS/CFT, Multitrace Deformations and New Instabilities of Nonlocal String Theories [PDF]

, 2003
We study "multitrace" deformations of large N master fields in models with a mass gap. In particular, we determine the conditions for the multitrace couplings to drive tachyonic instabilities.
A. Sever, C Hoyos, E. Witten, E. Witten, E. Witten, E. Witten, E. Witten, G.Korchemsky, G.T. Horowitz, H.S. Reall, I.R. Klebanov, J.L.F Barbon, J.M. Maldacena, J.M. Maldacena, M. Berkooz, N. Itzhaki, O. Aharony, O. Aharony, P. Minces, P. Minces, S.R. Das, S.S. Gubser, S.S. Gubser, S.W. Hawking   +23 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Observation of An Evolving Magnetic Flux Rope Prior To and During A Solar Eruption

, 2012
Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments.
B Kliem, CJ Schrijver, DE McKenzie, DM Rust, EN Parker, F Yuan, G Aulanier, J Zhang, JR Lemen, KP Dere, L Burlaga, LM Green, M Yamada, O Olmedo, P Kumar, R Liu, RL Moore, RP Lepping, S Zharkov, SE Gibson, SK Antiochos, T Hirayama, TP Intrator, VS Titov, W Daughton, X Cheng   +25 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Black hole phase transitions and the chemical potential

Physics Letters B, 2017
In the context of black hole thermodynamics and the AdS–CFT correspondence, we consider the chemical potential (μ) dual to the number of colours (N) of the boundary gauge theory, in the grand canonical ensemble.
Reevu Maity, Pratim Roy, Tapobrata Sarkar   +2 more
doaj   +1 more source

Threshold phenomena in erosion driven by subsurface flow

, 2004
We study channelization and slope destabilization driven by subsurface (groundwater) flow in a laboratory experiment. The pressure of the water entering the sandpile from below as well as the slope of the sandpile are varied.
Aharonson, Alexander E. Lobkovsky, Baker, Baker, Buffington, Dietrich, Dunne, Dunne, Dunne, Duran, Gomez, Higgins, Horton, Howard, Howard, Howard, Iverson, Izumi, Izumi, Kochel, Kochel, Kochel, Laity, Landau, Loewenherz, Martin, Montgomery, Montgomery, Owoputi, Schumm, Schörghofer, Shields, Smith, Taylor, Yalin   +34 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source