Results 121 to 130 of about 215,533 (345)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Do APOE4 and long COVID-19 increase the risk for neurodegenerative diseases in adverse environments and poverty?

Frontiers in Neuroscience, 2023
Gabriella C. V. Ciurleo, José Wagner Leonel Tavares-Júnior, Carlos Meton A. G. Vieira, Pedro Braga-Neto, Pedro Braga-Neto, Reinaldo B. Oriá   +5 more
doaj   +1 more source

Pediatric flecainide pharmacogenomics: a roadmap to delivering precision-based care to pediatrics arrhythmias

Frontiers in Pharmacology
Flecainide acetate is a Class 1c anti-arrhythmic with a potent sodium voltage gated channel blockade which is utilized for the second-line treatment of tachyarrhythmias in children and adults.
Ronald Palmen, Mollie Walton, Mollie Walton, Mollie Walton, Jonathan Wagner, Jonathan Wagner, Jonathan Wagner   +6 more
doaj   +1 more source

Finite-element modelling of mechanobiological factors influencing sesamoid tissue morphology in the patellar tendon of an ostrich [PDF]

, 2017
The appearance and shape of sesamoid bones within a tendon or ligament wrapping around a joint are understood to be influenced by both genetic and epigenetic factors.
Carter DR, Dye S, Hogg DA, Lansdown AB, Macalister A, Vickaryous MK, Wren TA   +6 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Phenotypic Plasticity in Juvenile Jellyfish Medusae Facilitates Effective Animal–Fluid Interaction [PDF]

, 2010
Locomotion and feeding in marine animals are intimately linked to the flow dynamics created by specialized body parts. This interaction is of particular importance during ontogeny, when changes in behaviour and scale challenge the organism with shifts in
Colin, Sean, Costello, John H., Dabiri, J. O., Feitl, K. E., Nawroth, J. C.   +4 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Fatty acid requirements in ontogeny of marine and freshwater fish

, 2010
Essential fatty acid (EFA) requirements vary qualitatively and quantitatively with both species and during ontogeny of fish, with early developmental stages and broodstock being critical periods.
D. Tocher
semanticscholar   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Fusión de suturas craneales en el delfín franciscana, Pontoporia blainvillei (Gervais and D'Orbigny, 1844) [PDF]

, 2015
Se estudió la fusión de suturas craneales y su asimetría bilateral en el delfín franciscana, Pontoporia blainvillei. Nuestros resultados mostraron que el cierre de suturas presenta baja variabilidad asociada a la longitud corporal total, exceptuando la ...
Cappozzo, Humberto Luis, del Castillo, Daniela Laura, Flores, David Alfredo   +2 more
core