Results 181 to 190 of about 223,364 (391)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

The Ontogeny of Osmoregulation and Its Neurosecretory Control In the Decapod Crustacean,Rhithropanopeus harrisii(Gould) [PDF]

, 1966
Frederick A. Kalber, John D. Costlow
openalex   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The Post-Tetrad Ontogeny of the Pollen Wall and the Chemical Structure of the Sporopollenin of Lilium Henryi [PDF]

, 1968
J. Brooks, G. Shaw
openalex   +1 more source

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

Science, 2016
F. Notta, Sasan Zandi, N. Takayama, Stephanie M. Dobson, O. Gan, Gavin W. Wilson, K. Kaufmann, Jessica Mcleod, E. Laurenti, C. Dunant, J. McPherson, Lincoln D. Stein, Y. Dror, J. Dick   +13 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Body-World Coupling, Sensorimotor Mechanisms, and the Ontogeny of Social Cognition

Frontiers in Psychology, 2020
Daniel Rojas-Líbano, Francisco J. Parada   +1 more
doaj   +1 more source

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

Neuron, 2018
F. C. Bennett, Mariko L. Bennett, Fazeela Yaqoob, Sara B. Mulinyawe, Gerald A. Grant, M. Hayden Gephart, E. Plowey, Ben A. Barres   +7 more
semanticscholar   +1 more source

Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra. [PDF]

, 2016
We recently described a two-step process of urethral plate canalization and urethral fold fusion to form the human penile urethra. Canalization ("opening zipper") opens the solid urethral plate into a groove, and fusion ("closing zipper") closes the ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald, Overland, Maya, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +6 more
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source