Results 51 to 60 of about 215,533 (345)

Ontogeny in the Family

open access: yesBehavior Genetics, 2005
When ontogeny takes place in a family, and parents provide essential resources for development, the parents become an environmental component to the development of a wide range of offspring traits. Because differences among parents may partly reflect genetic variation, this environmental component contains genes and may itself evolve.
openaire   +3 more sources

Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response

open access: yesPharmaceuticals, 2022
Pediatric cancer treatment has evolved significantly in recent decades. The implementation of risk stratification strategies and the selection of evidence-based chemotherapy combinations have improved survival outcomes.
Ashwin Kamath   +5 more
doaj   +1 more source

Extraordinary morphological changes in valve morphology during the ontogeny of several species of the Australian ostracod genus Bennelongia (Crustacea, Ostracoda) [PDF]

open access: yes, 2013
Ostracods belonging to the genus Bennelongia differ much in valve morphology between adults and juveniles. Adult valves are asymmetrical, characterised by a beak-like feature in the anteroventral region of the left valve, and, with some notable ...
De Deckker, Patrick, Martens, Koen
core   +3 more sources

Ontogeny of the Pain

open access: yesPhysiological Research, 2012
The article gives an overview of developmental aspects of the ontogeny of pain both in experimental models and in children. The whole article is devoted to the ontogenesis in pain perception and the possible influence on it. The role of endogenous opioids on the development of pain and other important substances such as serotonin, nerve growth factor ...
R, Rokyta, J, Fricová
openaire   +2 more sources

Toward a physiological explanation of juvenile growth curves [PDF]

open access: yes, 2020
Juvenile growth curves are generally sigmoid in shape: Growth is initially nearly exponential, but it slows to near zero as the animal approaches maturity.
Adair T.H.   +5 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

open access: yesClinical pharmacology and therapy, 2020
Clinical assessment of drug–drug interactions (DDIs) in children is not a common practice in drug development. Therefore, physiologically‐based pharmacokinetic (PBPK) modeling can be beneficial for informing drug labeling.
J. Lang   +4 more
semanticscholar   +1 more source

Temporal tracking of mineralization and transcriptional developments of shell formation during the early life history of pearl oyster Pinctada maxima [PDF]

open access: yes, 2011
Molluscan larval ontogeny is a highly conserved process comprising three principal developmental stages. A characteristic unique to each of these stages is shell design, termed prodissoconch I, prodissoconch II and dissoconch.
Elizur, Abigail   +3 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

Inflammatory Pain and Corticosterone Response in Infant Rats: Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress

open access: yesMediators of Inflammation, 2013
Our researches have shown that gestational stress causes exacerbation of inflammatory pain in the offspring; the maternal 5-HT1A agonist buspirone before the stress prevents the adverse effect.
Irina P. Butkevich   +5 more
doaj   +1 more source

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