Results 141 to 150 of about 169,797 (297)
Advanced Healthcare Materials, EarlyView.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett +7 more
wiley +1 more source
Eco-anxiety and the self in a warming world: Conceptualising ontologically insecure communities
European Journal of International SecurityWhile much work has been done on ontological security relating to the state’s sense of self, whether addressing the role of migration, globalisation, and even membership to supranational entities like the European Union, scholars have explored less how ...
Renato Fakhoury, Gabriella Gricius
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma +13 more
wiley +1 more source
Ontological beliefs and their impact on teaching elementary geometry [PDF]
, 2011 This paper proposes a conceptual framework to classify ontological beliefs on elementary geometry. As a first application, this framework is used to interpret nine interviews taken from secondary school teachers. The interpretation leads to the following
Girnat, Boris
core
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
A layered approach towards domain authoring support [PDF]
, 2002 This paper presents an approach to authoring support for Web courseware based on a layered ontological paradigm. The ontology-based layers in the courseware authoring architecture serve as a basis for formal semantics and reasoning support in performing ...
Cristea, A.I. +5 more
core
How Serious is our Ontological Commitment to Events as Individuals?
Principia: An International Journal of Epistemology, 2005 This paper aims at discussing the usage by Davidson as to events of Quine's criterion of ontological commitment. According to Davidson, we are ontologically committed to the existence of events as individuals as we employ literally terms such as ‘Caesar ...
Luiz Henrique de A. Dutra
doaj
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu +10 more
wiley +1 more source
ONTOLOGY, MATTER AND EMERGENCE [PDF]
, 2007 “Ontological emergence” of inherent high-level properties with causal powers is witnessed nowhere. A non-substantialist conception of emergence works much better.
Bitbol, Michel, Michel, Bitbol
core
Advanced Healthcare Materials, EarlyView.FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang +11 more
wiley +1 more source