Results 91 to 100 of about 300,638 (342)

Introducing narratives in Europeana: A case study

International Journal of Applied Mathematics and Computer Science, 2019
We present a preliminary study to introduce narratives as a first-class functionality in digital libraries. The general idea is to enrich those libraries with semantic networks of events providing a meaningful contextualisation of the digital libraries ...
Meghini Carlo, Bartalesi Valentina, Metilli Daniele, Benedetti Filippo   +3 more
doaj   +1 more source

Behavior change interventions: the potential of ontologies for advancing science and practice [PDF]

, 2016
A central goal of behavioral medicine is the creation of evidence-based interventions for promoting behavior change. Scientific knowledge about behavior change could be more effectively accumulated using "ontologies." In information science, an ontology ...
Ahern, David, Bartlett Ellis, Rebecca J., Cole-Lewis, Heather, Gibson, Bryan, Hekler, Eric B., Hesse, Bradford, Larsen, Kai R., Michie, Susan, Moser, Richard P., Spruijt-Metz, Donna, Yi, Jean   +10 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Using multiple reference ontologies: Managing composite annotations [PDF]

, 2009
There are a growing number of reference ontologies available across a variety of biomedical domains and current research focuses on their construction, organization and use.
Cook, Daniel L, Gennari, John H, Mejino, Jose L V, Neal, Maxwell L   +3 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Employing Ontology-Alignment and Locality-Sensitive Hashing to Improve Attribute Interoperability in Federated eID Systems

Complex Systems Informatics and Modeling Quarterly, 2016
Achieving interoperability, i.e. creating identity federations between different Electronic identities (eID) systems, has gained relevance throughout the past years.
Walter Priesnitz Filho, Carlos Ribeiro, Thomas Zefferer   +2 more
doaj   +1 more source

HiG2Vec: Hierarchical Representations of Gene Ontology and Genes in the Poincaré Ball [PDF]

, 2020
Jaesik Kim, Dokyoon Kim, Kyung-Ah Sohn
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Searching biomedical ontologies based on content [PDF]

, 2007
As more ontologies become publicly available, finding the 'right' ontologies becomes much harder. In this paper, we introduce a new ontology search technique which is based on corpus analysis.
Alani, Harith, Musen, Mark, Noy, Natasha, Shadbolt, Nigel, Shah, Nigam   +4 more
core