Results 91 to 100 of about 581,965 (380)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Ontology-based domain modelling for consistent content change management [PDF]
, 2010 Ontology-based modelling of multi-formatted software application content is a challenging area in content management. When the number of software content unit is huge and in continuous process of change, content change management is important.
Abgaz, Yalemisew +2 more
core +1 more source
Shiva: A Framework for Graph Based Ontology Matching [PDF]
, 2014 Since long, corporations are looking for knowledge sources which can provide structured description of data and can focus on meaning and shared understanding.
Darbari, Hemant +3 more
core +1 more source
Engineering Students' Thinking About Technical Systems: An Ontological Categories Approach
Frontiers in Education, 2020 This paper aims at identifying ontological categories as higher-order knowledge structures that underlie engineering students' thinking about technical systems.
Sarah Isabelle Hofer +3 more
doaj +1 more source
Decoherence and Ontology [PDF]
, 2019 This paper discusses the consequences of quantum mechanics for our understanding of physical reality, particularly regarding how classical concepts emerge from quantum laws; how common sense logic stands out as a special case of quantum logic applied to macroscopic objects; how causality and locality are found to be “provincial” consequences of quanta;
openaire +4 more sources
Canadian Journal of Philosophy, 2018 Parfit denies that the introduction of reasons into our ontology is costly for his theory. He puts forth two positions to help establish the claim: the Plural Senses View and the Argument from Empty Ontology. I argue that, first, the Plural Senses View for ‘exists’ can be expanded to allow for senses which undermine his ontological claims; second, the ...
openaire +4 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Using Cross-Lingual Explicit Semantic Analysis for Improving Ontology Translation [PDF]
, 2012 Semantic Web aims to allow machines to make inferences using the explicit conceptualisations contained in ontologies. By pointing to ontologies, Semantic Web-based applications are able to inter-operate and share common information easily.
Aggarwal, Nitish +3 more
core +2 more sources
Building a biomedical ontology recommender web service
Journal of Biomedical Semantics, 2010 Background Researchers in biomedical informatics use ontologies and terminologies to annotate their data in order to facilitate data integration and translational discoveries.
Jonquet Clement +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source