Results 101 to 110 of about 581,965 (380)

Conceptual modelling and the quality of ontologies: A comparison between object-role modelling and the object paradigm [PDF]

, 2010
Ontologies are key enablers for sharing precise and machine-understandable semantics among different applications and parties. Yet, for ontologies to meet these expectations, their quality must be of a good standard.
Al-Asswad, MM, Al-Debei, MM, de Cesare, S, Lycett, M   +3 more
core  

Big Data Analyses of Roman Tableware: information standards, digital technologies and research collaboration

Internet Archaeology, 2018
Archaeologists in the UK and elsewhere have developed standards and guidelines for recording, analysing and archiving information about Roman pottery. A survey of Roman pottery specialists conducted for the 'Big Data on the Roman Table' (BDRT) research ...
Sarah Colley, Jane Evans
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A formal theory for spatial representation and reasoning in biomedical ontologies [PDF]

, 2006
Objective: The objective of this paper is to demonstrate how a formal spatial theory can be used as an important tool for disambiguating the spatial information embodied in biomedical ontologies and for enhancing their automatic reasoning capabilities ...
Bittner, Thomas, Donnelly, Maureen, Rosse, Cornelius   +2 more
core   +2 more sources

A Study on the Ontologies Developed Based on the Principles of Open Biomedical Ontologies Foundry

پیاورد سلامت, 2019
Background and Aim: Ontologies facilitate data integration, exchange, searching and querying. Open Biomedical Ontologies (OBO) Foundry is a solution for creating reference ontologies.
Nader Alishan Karami, Mohsen Hajizeinalabedini, Iraj Radad, Seyed Javad Ghazi Mirsaeed   +3 more
doaj  

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Working with Ontologies

, 2016
Ontologies are powerful and popular tools to encode data in a structured format and manage knowledge. A large variety of existing ontologies offer users access to biomedical knowledge. This chapter contains a short theoretical background of ontologies and introduces two notable examples: The Gene Ontology and the ontology for Biological Pathways ...
Kramer, Frank, Beißbarth, Tim
openaire   +5 more sources

Ontology localization

Proceedings of the fifth international conference on Knowledge capture, 2009
nternational organizations (e.g., FAO1 , WHO2 , etc.) are increasingly expressing the need for multilingual ontologies for di®erent purposes, e.g., ontology-based multilingual machine translation, multilingual informa- tion retrieval. However, most of the ontologies built so far have mainly English or another natural language as basis.
Espinoza Mejía, Mauricio, Montiel Ponsoda, Elena, Gómez-Pérez, A.   +2 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pinning beetles, biobanking futures: practices of archiving life in a time of extinction

New Genetics and Society, 2018
Museums have been apparatuses for articulating knowledges, power and natures into an ordered whole for centuries, practices that have extended through to contemporary museums and their genetic collecting programs.
Adrian Van Allen
doaj   +1 more source