Results 101 to 110 of about 514,391 (335)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A Study on the Ontologies Developed Based on the Principles of Open Biomedical Ontologies Foundry

پیاورد سلامت, 2019
Background and Aim: Ontologies facilitate data integration, exchange, searching and querying. Open Biomedical Ontologies (OBO) Foundry is a solution for creating reference ontologies.
Nader Alishan Karami, Mohsen Hajizeinalabedini, Iraj Radad, Seyed Javad Ghazi Mirsaeed   +3 more
doaj  

Building a biomedical ontology recommender web service

Journal of Biomedical Semantics, 2010
Background Researchers in biomedical informatics use ontologies and terminologies to annotate their data in order to facilitate data integration and translational discoveries.
Jonquet Clement, Musen Mark A, Shah Nigam H   +2 more
doaj   +1 more source

Introducing narratives in Europeana: A case study

International Journal of Applied Mathematics and Computer Science, 2019
We present a preliminary study to introduce narratives as a first-class functionality in digital libraries. The general idea is to enrich those libraries with semantic networks of events providing a meaningful contextualisation of the digital libraries ...
Meghini Carlo, Bartalesi Valentina, Metilli Daniele, Benedetti Filippo   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Employing Ontology-Alignment and Locality-Sensitive Hashing to Improve Attribute Interoperability in Federated eID Systems

Complex Systems Informatics and Modeling Quarterly, 2016
Achieving interoperability, i.e. creating identity federations between different Electronic identities (eID) systems, has gained relevance throughout the past years.
Walter Priesnitz Filho, Carlos Ribeiro, Thomas Zefferer   +2 more
doaj   +1 more source

Semantic Similarity in Biomedical Ontologies

PLoS Comput. Biol., 2009
In recent years, ontologies have become a mainstream topic in biomedical research. When biological entities are described using a common schema, such as an ontology, they can be compared by means of their annotations.
Catia Pesquita, Daniel Faria, A. O. Falcão, P. Lord, Francisco M. Couto   +4 more
semanticscholar   +1 more source

Using multiple reference ontologies: Managing composite annotations [PDF]

, 2009
There are a growing number of reference ontologies available across a variety of biomedical domains and current research focuses on their construction, organization and use.
Cook, Daniel L, Gennari, John H, Mejino, Jose L V, Neal, Maxwell L   +3 more
core   +1 more source

Towards Desiderata for an Ontology of Diseases for the Annotation of Biological Datasets [PDF]

, 2009
There is a plethora of disease ontologies available, all potentially useful for the annotation of biological datasets. We define seven desirable features for such ontologies and examine whether or not these features are supported by eleven disease ...
Anita Burgun, Olivier Bodenreider
core   +3 more sources