Results 261 to 270 of about 581,965 (380)

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source

OntoTiger: a platform of ontology-based application tools for integrative biomedical exploration. [PDF]

Nucleic Acids Res
Yang H, He G, Zhang M, Fu H, He G, Wang C, Liu Y, Zhang S, Wang T, He YO, Cheng L.   +10 more
europepmc   +1 more source

Rethinking the Pornography Debate: Some Ontological Considerations

, 1998
Constance L. Mui
openalex   +2 more sources

Ontology Tools For Semantic Reconciliation in Distributed Heterogeneous Information Environments [PDF]

, 2000
Kuhanandha Mahalingam, Michael N. Huhns
openalex   +1 more source

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source

Annotation of biological samples data to standard ontologies with support from large language models. [PDF]

Comput Struct Biotechnol J
Riquelme-García A, Mulero-Hernández J, Fernández-Breis JT.   +2 more
europepmc   +1 more source

Document ontology based personalized filtering system (poster session) [PDF]

, 2000
Kyung-Sam Choi, Chi-Hoon Lee, Phill-Kyu Rhee   +2 more
openalex   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

OLS4: a new Ontology Lookup Service for a growing interdisciplinary knowledge ecosystem. [PDF]

Bioinformatics
McLaughlin J, Lagrimas J, Iqbal H, Parkinson H, Harmse H.   +4 more
europepmc   +1 more source

ON THE VIEW TO THE NATURE AND ONTOLOGICAL SPACE IN THE JAPANESE MODERN LITERARY WORKS

, 1999
Tetsuo Kidokoro
openalex   +2 more sources