Results 261 to 270 of about 514,391 (335)

A Perspective on Software Intelligence for Autonomous Transformations in Biomedical Data and Knowledge. [PDF]

Learn Health Syst
Navale V.
europepmc   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Epilepsy disease classification: a community effort to enhance the Mondo Disease Ontology. [PDF]

Database (Oxford)
Vasilevsky N, Gehrke S, Mullen K, Barua S, Braun I, Brünger T, Coughlin C, Ivaniuk A, Korn D, Lal D, Marsh S, O'Loughlin E, Olson D, Shwetar Y, Sofocleous C, Vogel-Farley V, Grabenstatter H, Haendel M, Mungall C, Toro S.   +19 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Recommendations for Standardizing Nuclear Medicine Terminology and Data in the Era of Theranostics and Artificial Intelligence. [PDF]

J Nucl Med
Bradshaw TJ, Brosch-Lenz J, Uribe C, Karakatsanis N, Bruce R, Strigari L, Jha A, Dutta J, Schwartz J, El Fakhri G, Avval A, Rahmim A, Saboury B.   +12 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Endocrine Disruption in Freshwater Cladocerans: Transcriptomic Network Perspectives on TBOEP and PFECHS Impacts in <i>Daphnia magna</i>. [PDF]

Int J Mol Sci
Kim HW, Yun SG, Park JY, Lee J, Han JP, Shin DY, Lee JH, Cho EM, Seo YR.   +8 more
europepmc   +1 more source

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis

Advanced Science, EarlyView.
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim, Ha Kyeong Lee, Zulfikar Azam, Jeong Uk Choi, Riajul Wahab, Na Kyeong Lee, Yoon Gun Ko, So‐Young Choi, Se‐Ra Lee, Wan Seob Shim, Taeeung Kim, In‐San Kim, Farzana Alam, Sang Yoon Kim, Seong Who Kim, Youngro Byun, Taslim A Al‐Hilal   +16 more
wiley   +1 more source

Multifaceted human gut microbiome data associated with health and nutrition. [PDF]

Front Microbiol
Maisto L, Telegrafo C, Rubino F, Santamaria M, Traka MH, Tullo A, Bouwman J, Sbisà E, Balech B.   +8 more
europepmc   +1 more source

Developing a Single‐Cell Spatial Transcriptomics Workflow for In Vivo Evaluation of Implanted Biomaterials

Advanced Science, EarlyView.
This work establishes a standardized, high‐resolution spatial transcriptomics workflow for characterizing host responses to biomaterial implants. Using the 10× Xenium platform, the pipeline integrates spatial mapping, subclustering, and functional enrichment to resolve immune and stromal cell organization at single‐cell resolution, enabling ...
Alex H.P. Chan, Yunfei Hu, Billie Pardavi, Xueying Xu, Angus J. Grant, Steven G. Wise, Lipin Loo, Richard P. Tan   +7 more
wiley   +1 more source