Results 281 to 290 of about 514,391 (335)

An ecological model in support of an ontology of mental functioning. [PDF]

PLOS Ment Health
Sacco MJ, Divita G, Coale K, Goldman HH, Rosé CP.   +4 more
europepmc   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

AgBioDatabase Finder: an online tool to help researchers find and submit agricultural genomic, genetic, and breeding data. [PDF]

MicroPubl Biol
Cabugos L, Buble K, Daenzer J, Jung S, Main D, Marrano A, Molik D, Raciti D, Wright A, Yook K, Reiser L.   +10 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

The missing link in FAIR data policy: biodata resources in life sciences. [PDF]

Sci Data
Poveda L, Farrell G, Tosatto SCE, Zahn-Zabal M, Ruch P, Gobeill J, Waterhouse RM, Dessimoz C.   +7 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Expanding and refining the Mammalian Phenotype Ontology to enhance disease model discovery. [PDF]

Dis Model Mech
Bello SM, Anagnostopoulos AV, Carmody LC, Matentzoglu N, Smith CL.   +4 more
europepmc   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

pyBiodatafuse: extending interoperability of data using modular queries across biomedical resources. [PDF]

Bioinformatics
Gadiya Y, Millán Acosta J, Ammar A, Adriaque Lozano A, Wetstede D, Martinát D, Sima AC, Mei H, Willighagen E, Abbassi-Daloii T.   +9 more
europepmc   +1 more source

Computational strategies for cross-species knowledge transfer. [PDF]

Nat Methods
Yuan H, Mancuso CA, Johnson K, Braasch I, Krishnan A.   +4 more
europepmc   +1 more source