Results 301 to 310 of about 276,244 (340)

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

High‐Efficiency Carriers’ Separation Strategy Based Ultrasmall‐Bandgap CuWO4 Sono‐Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy

Advanced Science, EarlyView.
This study prepares copper tungstate (CuWO4, CWO) nanoparticles for synergistic sono‐enhanced cuproptosis‐based cancer therapy. With an ultrasmall bandgap (1.71 eV), CWO facilitates efficient charge carrier separation under ultrasound, enhancing the generation of reactive oxygen species and the controlled release of Cu2+ ions cascade amplify oxidative ...
Lichao Zhu, Zhisheng Guo, Yu Luo, Haiyan Huang, Kexin Zhang, Bingbing Duan, Renmiao Peng, Haochen Yao, Chao Liang, Kaiyang Wang   +9 more
wiley   +1 more source

An Ontology-Based Approach for Understanding Appendicectomy Processes and Associated Resources. [PDF]

Healthcare (Basel)
Pathiraja Rathnayaka Hitige N, Song T, Craig SJ, Davis KJ, Hao X, Cui L, Yu P.   +6 more
europepmc   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Dynamic Retrieval Augmented Generation of Ontologies using Artificial Intelligence (DRAGON-AI). [PDF]

J Biomed Semantics
Toro S, Anagnostopoulos AV, Bello SM, Blumberg K, Cameron R, Carmody L, Diehl AD, Dooley DM, Duncan WD, Fey P, Gaudet P, Harris NL, Joachimiak MP, Kiani L, Lubiana T, Munoz-Torres MC, O'Neil S, Osumi-Sutherland D, Puig-Barbe A, Reese JT, Reiser L, Robb SM, Ruemping T, Seager J, Sid E, Stefancsik R, Weber M, Wood V, Haendel MA, Mungall CJ.   +29 more
europepmc   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage. [PDF]

Nat Methods
Börner K, Blood PD, Silverstein JC, Ruffalo M, Satija R, Teichmann SA, Pryhuber GJ, Misra RS, Purkerson JM, Fan J, Hickey JW, Molla G, Xu C, Zhang Y, Weber GM, Jain Y, Qaurooni D, Kong Y, HRA Team, Bueckle A, Herr BW.   +20 more
europepmc   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

Large language models for intelligent RDF knowledge graph construction: results from medical ontology mapping. [PDF]

Front Artif Intell
Mavridis A, Tegos S, Anastasiou C, Papoutsoglou M, Meditskos G.   +4 more
europepmc   +1 more source