Results 231 to 240 of about 950,377 (347)

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

open access: yesAdvanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan   +7 more
wiley   +1 more source

Towards a new vision of PaNET: enhancing reasoning capabilities for better photon and neutron data discovery. [PDF]

open access: yesJ Synchrotron Radiat
Tan T   +16 more
europepmc   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

open access: yesAdvanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang   +10 more
wiley   +1 more source

OntoTiger: a platform of ontology-based application tools for integrative biomedical exploration. [PDF]

open access: yesNucleic Acids Res
Yang H   +10 more
europepmc   +1 more source

Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity

open access: yesAdvanced Science, EarlyView.
The current bottleneck in metanephric mesenchyme (MM)‐derived nephron organoid development is the absence of a connected network of collecting ducts (CD) derived from the ureteric bud (UB). To address this limitation, this study proposes a hypoxia‐based differentiation method that mimics the natural renal developmental environment, enabling the ...
Hyeonji Lim   +6 more
wiley   +1 more source

BioPortal: an open community resource for sharing, searching, and utilizing biomedical ontologies. [PDF]

open access: yesNucleic Acids Res
Vendetti J   +10 more
europepmc   +1 more source

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