Results 231 to 240 of about 910,309 (299)

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

A general strategy for generating expert-guided, simplified views of ontologies. [PDF]

Sci Data
Caron AR, Puig-Barbe A, Quardokus EM, Balhoff JP, Belfiore J, Chipampe NJ, Hardi J, Herr BW, Kir H, Roncaglia P, Musen MA, Parkinson H, McLaughlin JA, Börner K, Osumi-Sutherland D.   +14 more
europepmc   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Scientific knowledge graph and ontology generation using open large language models.

Digit Discov
Oarga A, Hart M, Bran AM, Lederbauer M, Schwaller P.   +4 more
europepmc   +1 more source

Improving atlas-scale single-cell annotation models with hierarchical cross-entropy loss. [PDF]

Nat Comput Sci
Cultrera di Montesano S, D'Ascenzo D, Raghavan S, Amini AP, Winter PS, Crawford L.   +5 more
europepmc   +1 more source

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

The DO-KB knowledgebase 2026 update: expanding programmatic and language access. [PDF]

Nucleic Acids Res
Baron JA, Johnson CMS, Schor MA, Olley D, Nickel L, Felix V, Bello SM, Greene C, Lichenstein R, Bisordi K, Koka R, Bearer C, Macatangay R, Ada N, Ballenger K, Bliss E, Colliver L, Dobbins G, Heitzig H, Dixon S, Semesky P, Garth J, Fairchild M, Gaskin P, Zahid S, Castillo R, Edwards S, Widjaja A, Usui Y, Lynch E, Clarkson M, Detwiler T, Schriml LM.   +32 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Hybrid ConvNeXtV2-ViT Architecture with Ontology-Driven Explainability and Out-of-Distribution Awareness for Transparent Chest X-Ray Diagnosis. [PDF]

Diagnostics (Basel)
Almughamisi N, Abosamra G, Albar A, Saleh M.   +3 more
europepmc   +1 more source